Gene Information
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Gene Name
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ABCB4 |
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Gene ID
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5244
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Gene Full Name
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ATP binding cassette subfamily B member 4 |
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Gene Alias
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ABC21|GBD1|ICP3|MDR2|MDR2/3|MDR3|PFIC-3|PGY3 |
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Transcripts
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ENSG00000005471
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Virus
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HBV |
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Gene Type
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protein-coding |
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HPA Location Info
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Nucleoplasm, Plasma membrane;Focal adhesion sites, Cytosol; 
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Membrane Info
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Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
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Uniport_ID
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P21439
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HGNC ID
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HGNC:45
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OMIM ID
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171060 |
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Summary
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The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function. [provided by RefSeq, Jul 2008] |
Target gene [ABCB4] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 1009737 |
chr7 |
4 |
10 |
0 |
14 |
View |
| 1022895 |
chr7 |
4 |
10 |
0 |
14 |
View |
| 1024707 |
chr7 |
75 |
1 |
5 |
81 |
View |
| 1041541 |
chr7 |
3 |
1 |
0 |
4 |
View |
| 1041542 |
chr7 |
3 |
1 |
0 |
4 |
View |
Target gene [ABCB4] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE236281
|
RNA-seq |
12 |
Illumina MiSeq (Homo sapiens) |
|
C GSE35465
|
Chip-seq;RNA-seq |
6 |
Illumina HiSeq 2000 (Homo sapiens) |
|
C GSE68402
|
Chip-seq |
26 |
Illumina MiSeq (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens) |
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S GSE247322
|
scRNA-seq |
27 |
Illumina NovaSeq 6000 (Homo sapiens) |
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TCGA_LIHC_HBV
|
DNA methylation sequencing;RNA-seq |
97 |
TCGA |
|
C GSE270130
|
Chip-seq |
27 |
Illumina NovaSeq 6000 (Homo sapiens) |
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GSE224901
|
RNA-seq |
21 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
C GSE100400
|
Chip-seq;RNA-seq;4C_cccDNA |
31 |
Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Mus musculus) |
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GSE173897
|
RNA-seq |
95 |
Illumina HiSeq 4000 (Homo sapiens) |
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GSE262515
|
RNA-seq |
21 |
Illumina HiSeq 2500 (Homo sapiens);Illumina HiSeq 2500 (Mus musculus) |
|
GSE110345
|
RNA-seq |
4 |
Illumina HiSeq 2500 (Homo sapiens) |
|
C GSE131257
|
ATAC-seq;RNA-seq |
19 |
Illumina HiSeq 2500 (Homo sapiens) |
|
GSE94660
|
RNA-seq |
42 |
Illumina HiSeq 2500 (Homo sapiens) |
When the query gene is differentially changed in the dataset, a feature/violin plot will be displayed.
> Dataset: GSE247322 - Gene expression in cell subsets
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HBV Target gene Detail Information
