Virus Dataset Detail

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Dataset Information
Accession GSE247322
Status 2024/1/1
Title Association of HBsAg levels with differential gene expression in NK, CD8 T, and memory B cells in treated patients with chronic HBV
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Hepatitis B surface antigen (HBsAg) secretion may impact the immune response in chronic hepatitis B virus (HBV) infection. Therapeutic approaches to suppress HBsAg production are being investigated. Our study aims to examine the immunomodulatory effects of high and low levels of circulating HBsAg by analyzing single-cell RNA sequencing data (scRNAseq) from blood and liver fine-needle aspirates (FNA). This will help to better understand anti-HBV immunity.
Samples
GSM ID Sample info Characteristics Description
GSM7887137 HBsAg high group PBMC1 tissue:PBMCs; disease state:chronic hepatitis B patient; cell type:peripheral blood mononuclear cells; group:HBsAg high group; treatment:nucleoside analogues -
GSM7887138 HBsAg low group PBMC3 tissue:PBMCs; disease state:chronic hepatitis B patient; cell type:peripheral blood mononuclear cells; group:HBsAg low group; treatment:nucleoside analogues -
GSM7887139 HBsAg high group PBMC4 tissue:PBMCs; disease state:chronic hepatitis B patient; cell type:peripheral blood mononuclear cells; group:HBsAg high group; treatment:nucleoside analogues -
GSM7887140 HBsAg high group PBMC5 tissue:PBMCs; disease state:chronic hepatitis B patient; cell type:peripheral blood mononuclear cells; group:HBsAg high group; treatment:nucleoside analogues -
GSM7887141 HBsAg low group PBMC6 tissue:PBMCs; disease state:chronic hepatitis B patient; cell type:peripheral blood mononuclear cells; group:HBsAg low group; treatment:nucleoside analogues -
GSM7887142 HBsAg low group PBMC7 tissue:PBMCs; disease state:chronic hepatitis B patient; cell type:peripheral blood mononuclear cells; group:HBsAg low group; treatment:nucleoside analogues -
GSM7887143 HBsAg high group PBMC8 tissue:PBMCs; disease state:chronic hepatitis B patient; cell type:peripheral blood mononuclear cells; group:HBsAg high group; treatment:nucleoside analogues -
GSM7887144 HBsAg low group PBMC9 tissue:PBMCs; disease state:chronic hepatitis B patient; cell type:peripheral blood mononuclear cells; group:HBsAg low group; treatment:nucleoside analogues -
GSM7887145 HBsAg high group PBMC10 tissue:PBMCs; disease state:chronic hepatitis B patient; cell type:peripheral blood mononuclear cells; group:HBsAg high group; treatment:nucleoside analogues -
GSM7887146 HBsAg high group HBV_X210 (PBMC11) tissue:PBMCs; disease state:chronic hepatitis B patient; cell type:peripheral blood mononuclear cells; group:HBsAg high group; treatment:nucleoside analogues Sample was excluded in this study after clustering of PBMCs
GSM7887147 HBsAg high group HBV_X610 (PBMC12) tissue:PBMCs; disease state:chronic hepatitis B patient; cell type:peripheral blood mononuclear cells; group:HBsAg high group; treatment:nucleoside analogues -
GSM7887148 HBsAg low group HBV_X670 (PBMC13) tissue:PBMCs; disease state:chronic hepatitis B patient; cell type:peripheral blood mononuclear cells; group:HBsAg low group; treatment:nucleoside analogues -
GSM7887149 HBsAg high group HBV_X680 (PBMC14) tissue:PBMCs; disease state:chronic hepatitis B patient; cell type:peripheral blood mononuclear cells; group:HBsAg high group; treatment:nucleoside analogues -
GSM7887157 HBsAg high group FNA4 tissue:FNAs; disease state:chronic hepatitis B patient; cell type:liver fine-needle aspirates; group:HBsAg high group; treatment:nucleoside analogues -
GSM7887150 HBsAg low group HBV_X726 (PBMC15) tissue:PBMCs; disease state:chronic hepatitis B patient; cell type:peripheral blood mononuclear cells; group:HBsAg low group; treatment:nucleoside analogues -
GSM7887158 HBsAg high group FNA5 tissue:FNAs; disease state:chronic hepatitis B patient; cell type:liver fine-needle aspirates; group:HBsAg high group; treatment:nucleoside analogues -
GSM7887151 HBsAg low group HBV_X842 (PBMC16) tissue:PBMCs; disease state:chronic hepatitis B patient; cell type:peripheral blood mononuclear cells; group:HBsAg low group; treatment:nucleoside analogues -
GSM7887152 HBsAg high group HBV_X846 (PBMC17) tissue:PBMCs; disease state:chronic hepatitis B patient; cell type:peripheral blood mononuclear cells; group:HBsAg high group; treatment:nucleoside analogues -
GSM7887159 HBsAg low group FNA6 tissue:FNAs; disease state:chronic hepatitis B patient; cell type:liver fine-needle aspirates; group:HBsAg low group; treatment:nucleoside analogues -
GSM7887153 HBsAg high group HBV_X861 (PBMC18) tissue:PBMCs; disease state:chronic hepatitis B patient; cell type:peripheral blood mononuclear cells; group:HBsAg high group; treatment:nucleoside analogues -
GSM7887160 HBsAg low group FNA7 tissue:FNAs; disease state:chronic hepatitis B patient; cell type:liver fine-needle aspirates; group:HBsAg low group; treatment:nucleoside analogues -
GSM7887154 HBsAg low group HBV_X980 (PBMC19) tissue:PBMCs; disease state:chronic hepatitis B patient; cell type:peripheral blood mononuclear cells; group:HBsAg low group; treatment:nucleoside analogues -
GSM7887155 HBsAg low group HBV_X983 (PBMC20) tissue:PBMCs; disease state:chronic hepatitis B patient; cell type:peripheral blood mononuclear cells; group:HBsAg low group; treatment:nucleoside analogues -
GSM7887156 HBsAg high group FNA1 tissue:FNAs; disease state:chronic hepatitis B patient; cell type:liver fine-needle aspirates; group:HBsAg high group; treatment:nucleoside analogues -
GSM7887161 HBsAg high group FNA8 tissue:FNAs; disease state:chronic hepatitis B patient; cell type:liver fine-needle aspirates; group:HBsAg high group; treatment:nucleoside analogues -
GSM7887162 HBsAg low group FNA9 tissue:FNAs; disease state:chronic hepatitis B patient; cell type:liver fine-needle aspirates; group:HBsAg low group; treatment:nucleoside analogues -
GSM7887163 HBsAg high group FNA10 tissue:FNAs; disease state:chronic hepatitis B patient; cell type:liver fine-needle aspirates; group:HBsAg high group; treatment:nucleoside analogues -
Platform GPL24676  : Illumina NovaSeq 6000 (Homo sapiens)
Literature 38314025  
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scRNA-seq UMAP