Gene Information
|
Gene Name
|
ABL2 |
|
Gene ID
|
27
|
|
Gene Full Name
|
ABL proto-oncogene 2, non-receptor tyrosine kinase |
|
Gene Alias
|
ABLL|ARG |
|
Transcripts
|
ENSG00000143322
|
|
Virus
|
HTLV1 |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Cytosol;Intermediate filaments; 
|
|
Membrane Info
|
Cancer-related genes, Enzymes, Predicted intracellular proteins, RAS pathway related proteins |
|
Uniport_ID
|
P42684
|
|
HGNC ID
|
HGNC:77
|
|
OMIM ID
|
164690 |
|
Summary
|
This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009] |
Target gene [ABL2] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 6002241 |
chr1 |
249 |
7 |
10 |
266 |
View |
| 6019261 |
chr1 |
8 |
0 |
0 |
8 |
View |
| 6023249 |
chr1 |
3 |
1 |
0 |
4 |
View |
Target gene [ABL2] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE189602
|
Methylation profiling (Array) |
4 |
Infinium MethylationEPIC |
|
C GSE94732
|
Chip-seq |
24 |
Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens) |
|
GSE52244
|
Expression array |
15 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version] |
|
GSE10789
|
Expression array |
6 |
NCI/ATC Hs-OperonV3 |
|
GSE224047
|
RNA-seq |
10 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE168557
|
Expression array |
6 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version) |
|
GSE136189
|
Methylation profiling (Array) |
40 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE94732 - ABL2 peak across samples
|
Peak Plot
|
|
|
HTLV1 Target gene Detail Information
