Gene Name	APTX
Gene ID	54840
Gene Full Name	aprataxin
Gene Alias	AOA|AOA1|AXA1|EAOH|EOAHA|FHA-HIT
Transcripts	ENSG00000137074
Virus	HBV
Gene Type	protein-coding
HPA Location Info	Nucleoplasm, Nucleoli;
Membrane Info	Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Uniport_ID	Q7Z2E3
HGNC ID	HGNC:15984
OMIM ID	606350
Summary	This gene encodes a member of the histidine triad (HIT) superfamily. The encoded protein may play a role in single-stranded DNA repair through its nucleotide-binding activity and its diadenosine polyphosphate hydrolase activity. Mutations in this gene have been associated with ataxia-ocular apraxia. Alternatively spliced transcript variants have been identified for this gene.[provided by RefSeq, Aug 2010]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1011571	chr9	2	6	0	8	View
1013879	chr9	1	3	0	4	View
1017275	chr9	1	0	0	1	View

Data ID	Experiment type	Sample number	Platform
GSE236281	RNA-seq	12	Illumina MiSeq (Homo sapiens)
C   GSE35465	Chip-seq;RNA-seq	6	Illumina HiSeq 2000 (Homo sapiens)
C   GSE68402	Chip-seq	26	Illumina MiSeq (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens)
TCGA_LIHC_HBV	DNA methylation sequencing;RNA-seq	97	TCGA
C   GSE270130	Chip-seq	27	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE64877	Chip-seq	2	Illumina Genome Analyzer (Homo sapiens)
GSE224901	RNA-seq	21	Illumina NovaSeq 6000 (Homo sapiens)
GSE100400	Chip-seq;RNA-seq;4C_cccDNA	31	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Mus musculus)
GSE173897	RNA-seq	95	Illumina HiSeq 4000 (Homo sapiens)
GSE262515	RNA-seq	21	Illumina HiSeq 2500 (Homo sapiens);Illumina HiSeq 2500 (Mus musculus)
GSE110345	RNA-seq	4	Illumina HiSeq 2500 (Homo sapiens)
C   GSE131257	ATAC-seq;RNA-seq	19	Illumina HiSeq 2500 (Homo sapiens)
GSE94660	RNA-seq	42	Illumina HiSeq 2500 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE35465 - APTX peak across samples

Peak Plot

> Dataset: GSE68402 - APTX peak across samples

Peak Plot

> Dataset: GSE270130 - APTX peak across samples

Peak Plot

> Dataset: GSE64877 - APTX peak across samples

Peak Plot

> Dataset: GSE131257 - APTX peak across samples

Peak Plot