Gene Name	BACE2
Gene ID	25825
Gene Full Name	beta-secretase 2
Gene Alias	AEPLC|ALP56|ASP1|ASP21|BAE2|CDA13|CEAP1|DRAP
Transcripts	ENSG00000182240
Virus	HTLV1
Gene Type	protein-coding
HPA Location Info	Intracellular and membrane;
Membrane Info	Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Uniport_ID	Q9Y5Z0
HGNC ID	HGNC:934
OMIM ID	605668
Summary	This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6004321	chr21	92	20	7	119	View
6011164	chr21	23	4	0	27	View
6018589	chr21	8	1	0	9	View
6029032	chr21	1	0	0	1	View

Data ID	Experiment type	Sample number	Platform
GSE189602	Methylation profiling (Array)	4	Infinium MethylationEPIC
C   GSE94732	Chip-seq	24	Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)
GSE52244	Expression array	15	[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]
GSE224047	RNA-seq	10	Illumina NextSeq 500 (Homo sapiens)
GSE168557	Expression array	6	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version)
GSE136189	Methylation profiling (Array)	40	Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE94732 - BACE2 peak across samples

Peak Plot