Gene Information
|
Gene Name
|
BTRC |
|
Gene ID
|
8945
|
|
Gene Full Name
|
beta-transducin repeat containing E3 ubiquitin protein ligase |
|
Gene Alias
|
BETA-TRCP|FBW1A|FBXW1|FBXW1A|FWD1|bTrCP|bTrCP1|betaTrCP |
|
Transcripts
|
ENSG00000166167
|
|
Virus
|
MCV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Nucleoplasm;Plasma membrane, Cytosol; 
|
|
Membrane Info
|
Predicted intracellular proteins |
|
Uniport_ID
|
Q9Y297
|
|
HGNC ID
|
HGNC:1144
|
|
OMIM ID
|
603482 |
|
Summary
|
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012] |
Target gene [BTRC] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
Target gene [BTRC] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
C GSE147406
|
Chip-seq |
39 |
Illumina NextSeq 500 (Homo sapiens) |
|
C GSE124856
|
Chip-seq |
8 |
Illumina NextSeq 500 (Homo sapiens) |
|
C GSE230758
|
Chip-seq |
20 |
Illumina HiSeq 2500 (Homo sapiens) |
|
C GSE69877
|
Chip-seq |
10 |
Illumina HiSeq 2000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens) |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE147406 - BTRC peak across samples
|
Peak Plot
|
> Dataset: GSE124856 - BTRC peak across samples
|
Peak Plot
|
> Dataset: GSE230758 - BTRC peak across samples
|
Peak Plot
|
> Dataset: GSE69877 - BTRC peak across samples
|
Peak Plot
|
|
|
MCV Target gene Detail Information
