Accession	GSE230758
Status	2024/4/4
Title	Merkel cell polyomavirus small tumor antigen contributes to immune evasion by interfering with type I interferon signaling [ChIP-Seq]
Organism	Homo sapiens
Experiment type	Genome binding/occupancy profiling by high throughput sequencing
Summary	Merkel cell polyomavirus (MCPyV) is linked to Merkel cell carcinoma (MCC), a rare and aggressive skin cancer. This study investigated the influence of MCPyV T antigens on the host genome using transcriptomics and epigenomics. Results revealed a role for the small Tumor (sT) antigen in subverting type I interferon response and immune evasion, contributing to persistent infection and tumor progression. These findings enhance our understanding of MCPyV pathogenesis and may inform new therapeutic strategies.
Samples	GSM ID Sample info Characteristics Description GSM7233783 V_8_1_7, p604, day8, DonorII, H3K9me3 cell line:NHDF; cell type:sT; chip antibody:H3K9me3 - GSM7233784 V_8_1_8, p601, day8, DonorI, H3K27ac cell line:NHDF; cell type:mCherry control; chip antibody:H3K27ac - GSM7233785 V_8_1_8, p601, day8, DonorII,H3K27ac cell line:NHDF; cell type:mCherry control; chip antibody:H3K27ac - GSM7233786 V_8_1_8, p604, day8, DonorI, H3K27ac cell line:NHDF; cell type:sT; chip antibody:H3K27ac - GSM7233787 V_8_1_8, p604, day8, DonorII, H3K27ac cell line:NHDF; cell type:sT; chip antibody:H3K27ac - GSM7233788 V_8_1_6, p601, day8, DonorI, Input cell line:NHDF; cell type:mCherry control; chip antibody:none - GSM7233789 V_8_1_5, p601, day8, DonorII, Input cell line:NHDF; cell type:mCherry control; chip antibody:none - GSM7233790 V_8_1_6, p604, day8, DonorI, Input cell line:NHDF; cell type:sT; chip antibody:none - GSM7233791 V_8_1_5, p604, day8, DonorII, Input cell line:NHDF; cell type:sT; chip antibody:none - GSM7233772 V_8_1_6, p601, day8, DonorI, H3K4me3 cell line:NHDF; cell type:mCherry control; chip antibody:H3K4me3 - GSM7233773 V_8_1_5, p601, day8, DonorII, H3K4me3 cell line:NHDF; cell type:mCherry control; chip antibody:H3K4me3 - GSM7233774 V_8_1_6, p604, day8, DonorI, H3K4me3 cell line:NHDF; cell type:sT; chip antibody:H3K4me3 - GSM7233775 V_8_1_5, p604, day8, DonorII, H3K4me3 cell line:NHDF; cell type:sT; chip antibody:H3K4me3 - GSM7233776 V_8_1_6, p601, day8, DonorI, H3K27me3 cell line:NHDF; cell type:mCherry control; chip antibody:H3K27me3 - GSM7233777 V_8_1_5, p601, day8, DonorII, H3K27me3 cell line:NHDF; cell type:mCherry control; chip antibody:H3K27me3 - GSM7233778 V_8_1_6, p604, day8, DonorI, H3K27me3 cell line:NHDF; cell type:sT; chip antibody:H3K27me3 - GSM7233779 V_8_1_5, p604, day8, DonorII, H3K27me3 cell line:NHDF; cell type:sT; chip antibody:H3K27me3 - GSM7233780 V_8_1_7, p601, day8, DonorI, H3K9me3 cell line:NHDF; cell type:mCherry control; chip antibody:H3K9me3 - GSM7233781 V_8_1_7, p601, day8, DonorII, H3K9me3 cell line:NHDF; cell type:mCherry control; chip antibody:H3K9me3 - GSM7233782 V_8_1_7, p604, day8, DonorI, H3K9me3 cell line:NHDF; cell type:sT; chip antibody:H3K9me3 -
Platform	GPL16791  : Illumina HiSeq 2500 (Homo sapiens)
Literature
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