Gene Name	CACNA2D3
Gene ID	55799
Gene Full Name	calcium voltage-gated channel auxiliary subunit alpha2delta 3
Gene Alias	HSA272268
Transcripts	ENSG00000157445
Virus	HTLV1
Gene Type	protein-coding
HPA Location Info	Nucleoplasm, Principal piece;
Membrane Info	FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Uniport_ID	Q8IZS8
HGNC ID	HGNC:15460
OMIM ID	606399
Summary	This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6006765	chr3	56	5	2	63	View
6008911	chr3	16	23	2	41	View
6010814	chr3	15	11	3	29	View
6012174	chr3	0	1	22	23	View
6012266	chr3	7	9	7	23	View
6017883	chr3	10	0	0	10	View
6019103	chr3	3	3	2	8	View
6020899	chr3	2	2	2	6	View
6021042	chr3	4	2	0	6	View
6021534	chr3	5	1	0	6	View
6022127	chr3	4	1	0	5	View
6023283	chr3	4	0	0	4	View
6023617	chr3	4	0	0	4	View
6023839	chr3	2	2	0	4	View
6029298	chr3	1	0	0	1	View
6033081	chr3	0	0	0	0	View

Data ID	Experiment type	Sample number	Platform
GSE189602	Methylation profiling (Array)	4	Infinium MethylationEPIC
C   GSE94732	Chip-seq	24	Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)
GSE52244	Expression array	15	[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]
GSE10789	Expression array	6	NCI/ATC Hs-OperonV3
GSE224047	RNA-seq	10	Illumina NextSeq 500 (Homo sapiens)
GSE168557	Expression array	6	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version)
GSE136189	Methylation profiling (Array)	40	Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE94732 - CACNA2D3 peak across samples

Peak Plot