Gene Information
|
Gene Name
|
CD4 |
|
Gene ID
|
920
|
|
Gene Full Name
|
CD4 molecule |
|
Gene Alias
|
CD4mut|IMD79|Leu-3|OKT4D|T4 |
|
Transcripts
|
ENSG00000010610
|
|
Virus
|
YFV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Plasma membrane; 
|
|
Membrane Info
|
CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
|
Uniport_ID
|
P01730
|
|
HGNC ID
|
HGNC:1678
|
|
OMIM ID
|
186940 |
|
Summary
|
This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, May 2020] |
Target gene [CD4] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
Target gene [CD4] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE243442
|
RNA-seq |
55 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE99081
|
RNA-seq |
24 |
Illumina HiSeq 2500 (Homo sapiens) |
|
|
YFV Target gene Detail Information
