Gene Name	CD8A
Gene ID	925
Gene Full Name	CD8 subunit alpha
Gene Alias	CD8|CD8alpha|IMD116|Leu2|p32
Transcripts	ENSG00000153563
Virus	VZV
Gene Type	protein-coding
HPA Location Info	Plasma membrane;Intracellular and membrane;
Membrane Info	CD markers, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	P01732
HGNC ID	HGNC:1706
OMIM ID	186910
Summary	The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein. [provided by RefSeq, May 2020]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	34960186	S593A	gE	ORF68		I T	View
2	34960186	S595A	gE	ORF68		I T	View
3	34960186	T596A	gE	ORF68		I T	View
4	34960186	T598A	gE	ORF68		I T	View
5	34960186	Y569A	gE	ORF68		I T	View

Data ID	Experiment type	Sample number	Platform
GSE121385	RNA-seq	6	Illumina HiSeq 2500 (Homo sapiens)
GSE120375	RNA-seq	24	Illumina HiSeq 2500 (Homo sapiens)
GSE175797	RNA-seq	6	Illumina NextSeq 500 (Homo sapiens)