Gene Name	CDK1
Gene ID	983
Gene Full Name	cyclin dependent kinase 1
Gene Alias	CDC2|CDC28A|P34CDC2
Transcripts	ENSG00000170312
Virus	VZV
Gene Type	protein-coding
HPA Location Info	Nucleoplasm, Cytosol;Acrosome, Perinuclear theca, Connecting piece, Flagellar centriole;
Membrane Info	Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Transporters
Uniport_ID	P06493
HGNC ID	HGNC:1722
OMIM ID	116940
Summary	The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2023]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	9882337	S343A	gI	ORF67	Chickenpox	T	View

Data ID	Experiment type	Sample number	Platform
GSE121385	RNA-seq	6	Illumina HiSeq 2500 (Homo sapiens)
GSE120375	RNA-seq	24	Illumina HiSeq 2500 (Homo sapiens)
GSE175797	RNA-seq	6	Illumina NextSeq 500 (Homo sapiens)