Gene Information
|
Gene Name
|
CPE |
|
Gene ID
|
1363
|
|
Gene Full Name
|
carboxypeptidase E |
|
Gene Alias
|
BDVS|CPH|IDDHH |
|
Transcripts
|
ENSG00000109472
|
|
Virus
|
HTLV1 |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Vesicles, Centrosome;Intracellular and membrane; 
|
|
Membrane Info
|
Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
|
Uniport_ID
|
P16870
|
|
HGNC ID
|
HGNC:2303
|
|
OMIM ID
|
114855 |
|
Summary
|
This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015] |
Target gene [CPE] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 6019824 |
chr4 |
3 |
4 |
0 |
7 |
View |
| 6024693 |
chr4 |
1 |
1 |
1 |
3 |
View |
| 6024995 |
chr4 |
2 |
1 |
0 |
3 |
View |
| 6028144 |
chr4 |
1 |
0 |
0 |
1 |
View |
| 6029706 |
chr4 |
1 |
0 |
0 |
1 |
View |
Target gene [CPE] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
C GSE94732
|
Chip-seq |
24 |
Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens) |
|
GSE168557
|
Expression array |
6 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version) |
|
GSE52244
|
Expression array |
15 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version] |
|
GSE10789
|
Expression array |
6 |
NCI/ATC Hs-OperonV3 |
|
GSE189602
|
Methylation profiling (Array) |
4 |
Infinium MethylationEPIC |
|
GSE136189
|
Methylation profiling (Array) |
40 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE94732 - CPE peak across samples
|
Peak Plot
|
|
|
HTLV1 Target gene Detail Information
