Gene Information
|
Gene Name
|
CPSF4 |
|
Gene ID
|
10898
|
|
Gene Full Name
|
cleavage and polyadenylation specific factor 4 |
|
Gene Alias
|
CPSF30|NAR|NEB-1|NEB1 |
|
Transcripts
|
ENSG00000160917
|
|
Virus
|
IV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Nucleoplasm;Vesicles; 
|
|
Membrane Info
|
Plasma proteins, Predicted intracellular proteins |
|
Uniport_ID
|
O95639
|
|
HGNC ID
|
HGNC:2327
|
|
OMIM ID
|
603052 |
|
Summary
|
Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
Target gene [CPSF4] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
Target gene [CPSF4] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
C GSE225706
|
Chip-seq |
6 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE135069
|
RNA-seq |
10 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
C GSE113702
|
Chip-seq |
52 |
Illumina NextSeq 500 (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens) |
|
C GSE225704
|
ATAC-seq |
3 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
C GSE156060
|
Chip-seq;RNA-seq |
28 |
Illumina NovaSeq 6000 (Homo sapiens) |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE225706 - CPSF4 peak across samples
|
Peak Plot
|
> Dataset: GSE113702 - CPSF4 peak across samples
|
Peak Plot
|
> Dataset: GSE225704 - CPSF4 peak across samples
|
Peak Plot
|
> Dataset: GSE156060 - CPSF4 peak across samples
|
Peak Plot
|
|
|
IV Target gene Detail Information
