Virus Dataset Detail

> Detail information for each sample

Dataset Information
Accession GSE156060
Status 2020/8/12
Title Influenza non-structural protein 1 (NS1) localization plays a key role in the anatagonism of host antiviral processes
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing;Genome binding/occupancy profiling by high throughput sequencing
Summary The influenza virus is opportunistic by nature and is capable of subverting cellular signalling pathways for the benefit of viral replication. The function of non-structural protein 1 (NS1) as a core component for the influenza virus to interfere with host antiviral activity has been well cited in literature. However, the mechanism as to how NS1 is capble of subverting the host's innate immune system is unknown. NS1 has a unique capability to migrate between both the cytoplasm and nucleus of infected cells. To assess if NS1 interference operates a stratagy pertaining to a mechanism involved with nuclear-located signalling processes we designed two mutant virsus; WSNdelNS1 which encodes a deletion to prevent complete NS1 expression and WSN3M which encodes a NS1-variant that is defective in NS1 nuclear-translocation, thus preventing NS1 from entering the nuclus of infected cells.
Samples
GSM ID Sample info Characteristics Description
GSM4721532 Mock input replicate:1; viral strain:Uninfected; chip antibody:none; moi:0; h.p.i:8 hours Mock input (10%)
GSM4721533 WSN3M_input replicate:1; viral strain:WSN3M; chip antibody:none; moi:2; h.p.i:8 hours WSN3M_input (10%)
GSM4721534 WSNdelNS1_input replicate:1; viral strain:WSNdelNS1; chip antibody:none; moi:2; h.p.i:8 hours WSNdelNS1_input (10%)
GSM4721535 WSNWT_input replicate:1; viral strain:Wildtype (H1N1); chip antibody:none; moi:2; h.p.i:8 hours WSNWT_input (10%)
GSM4721536 Pol2_Mock replicate:1; viral strain:Uninfected; chip antibody:PolII (Millipore-05-623); moi:0; h.p.i:8 hours Pol2_Mock
GSM4721537 Pol2_s5p_Mock replicate:1; viral strain:Uninfected; chip antibody:PolII-s5p (Abcam-ab5131); moi:0; h.p.i:8 hours Pol2_s5p_Mock
GSM4721538 Pol2_s2p_Mock replicate:1; viral strain:Uninfected; chip antibody:PolII-s2p (Abcam-ab5095); moi:0; h.p.i:8 hours Pol2_s2p_Mock
GSM4721539 Pol2_WSN3M replicate:1; viral strain:WSN3M; chip antibody:PolII (Millipore-05-623); moi:2; h.p.i:8 hours Pol2_WSN3M
GSM4721540 Pol2_s5p_WSN3M replicate:1; viral strain:WSN3M; chip antibody:PolII-s5p (Abcam-ab5131); moi:2; h.p.i:8 hours Pol2_s5p_WSN3M
GSM4721541 Pol2_s2p_WSN3M replicate:1; viral strain:WSN3M; chip antibody:PolII-s2p (Abcam-ab5095); moi:2; h.p.i:8 hours Pol2_s2p_WSN3M
GSM4721542 Pol2_WSNdelNS1 replicate:1; viral strain:WSNdelNS1; chip antibody:PolII (Millipore-05-623); moi:2; h.p.i:8 hours Pol2_WSNdelNS1
GSM4721543 Pol2_s5p_WSNdelNS1 replicate:1; viral strain:WSNdelNS1; chip antibody:PolII-s5p (Abcam-ab5131); moi:2; h.p.i:8 hours Pol2_s5p_WSNdelNS1
GSM4721544 Pol2_s2p_WSNdelNS1 replicate:1; viral strain:WSNdelNS1; chip antibody:PolII-s2p (Abcam-ab5095); moi:2; h.p.i:8 hours Pol2_s2p_WSNdelNS1
GSM4721545 Pol2_WSNWT replicate:1; viral strain:Wildtype (H1N1); chip antibody:PolII (Millipore-05-623); moi:2; h.p.i:8 hours Pol2_WSNWT
GSM4721546 Pol2_s5p_WSNWT replicate:1; viral strain:Wildtype (H1N1); chip antibody:PolII-s5p (Abcam-ab5131); moi:2; h.p.i:8 hours Pol2_s5p_WSNWT
GSM4721547 Pol2_s2p_WSNWT replicate:1; viral strain:Wildtype (H1N1); chip antibody:PolII-s2p (Abcam-ab5095); moi:2; h.p.i:8 hours Pol2_s2p_WSNWT
GSM4721548 MOCK-1 replicate:1; viral strain:Uninfected; moi:0; h.p.i:8 hours MOCK-1
GSM4721549 MOCK-2 replicate:2; viral strain:Uninfected; moi:0; h.p.i:8 hours MOCK-2
GSM4721550 MOCK-3 replicate:3; viral strain:Uninfected; moi:0; h.p.i:8 hours MOCK-3
GSM4721551 WSN-3M-1 replicate:1; viral strain:WSN3M; moi:1; h.p.i:8 hours WSN-3M-1
GSM4721552 WSN-3M-2 replicate:2; viral strain:WSN3M; moi:1; h.p.i:8 hours WSN-3M-2
GSM4721553 WSN-3M-3 replicate:3; viral strain:WSN3M; moi:1; h.p.i:8 hours WSN-3M-3
GSM4721554 WSNWT-1 replicate:1; viral strain:Wildtype (H1N1); moi:1; h.p.i:8 hours WSNWT-1
GSM4721555 WSNWT-2 replicate:2; viral strain:Wildtype (H1N1); moi:1; h.p.i:8 hours WSNWT-2
GSM4721556 WSNWT-3 replicate:3; viral strain:Wildtype (H1N1); moi:1; h.p.i:8 hours WSNWT-3
GSM4721557 WSNdelNS1-1 replicate:1; viral strain:WSNdelNS1; moi:1; h.p.i:8 hours WSNdelNS1-1
GSM4721558 WSNdelNS1-2 replicate:2; viral strain:WSNdelNS1; moi:1; h.p.i:8 hours WSNdelNS1-2
GSM4721559 WSNdelNS1-3 replicate:3; viral strain:WSNdelNS1; moi:1; h.p.i:8 hours WSNdelNS1-3
Platform GPL24676  : Illumina NovaSeq 6000 (Homo sapiens)
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xCell Plot
* p<0.05 ** p<0.01