Gene Information
|
Gene Name
|
DENND1A |
|
Gene ID
|
57706
|
|
Gene Full Name
|
DENN domain containing 1A |
|
Gene Alias
|
FAM31A|KIAA1608 |
|
Transcripts
|
ENSG00000119522
|
|
Virus
|
HTLV1 |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Vesicles, Cytosol; 
|
|
Membrane Info
|
Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
|
Uniport_ID
|
Q8TEH3
|
|
HGNC ID
|
HGNC:29324
|
|
OMIM ID
|
613633 |
|
Summary
|
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010] |
Target gene [DENND1A] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 6013485 |
chr9 |
2 |
13 |
4 |
19 |
View |
| 6014937 |
chr9 |
14 |
1 |
0 |
15 |
View |
| 6014959 |
chr9 |
14 |
1 |
0 |
15 |
View |
| 6014960 |
chr9 |
14 |
1 |
0 |
15 |
View |
| 6027179 |
chr9 |
1 |
0 |
1 |
2 |
View |
Target gene [DENND1A] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE189602
|
Methylation profiling (Array) |
4 |
Infinium MethylationEPIC |
|
C GSE94732
|
Chip-seq |
24 |
Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens) |
|
GSE52244
|
Expression array |
15 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version] |
|
GSE10789
|
Expression array |
6 |
NCI/ATC Hs-OperonV3 |
|
GSE224047
|
RNA-seq |
10 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE168557
|
Expression array |
6 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version) |
|
GSE136189
|
Methylation profiling (Array) |
40 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE94732 - DENND1A peak across samples
|
Peak Plot
|
|
|
HTLV1 Target gene Detail Information
