Gene Information
|
Gene Name
|
DOCK1 |
|
Gene ID
|
1793
|
|
Gene Full Name
|
dedicator of cytokinesis 1 |
|
Gene Alias
|
DOCK180|ced5 |
|
Transcripts
|
ENSG00000150760
|
|
Virus
|
HTLV1 |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Nucleoplasm, Cytosol;Nucleoli, Plasma membrane, Actin filaments, Focal adhesion sites; 
|
|
Membrane Info
|
Plasma proteins, Predicted intracellular proteins |
|
Uniport_ID
|
Q14185
|
|
HGNC ID
|
HGNC:2987
|
|
OMIM ID
|
601403 |
|
Summary
|
This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] |
Target gene [DOCK1] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 6007388 |
chr10 |
3 |
47 |
6 |
56 |
View |
| 6017181 |
chr10 |
11 |
0 |
0 |
11 |
View |
| 6019450 |
chr10 |
7 |
1 |
0 |
8 |
View |
| 6021377 |
chr10 |
4 |
2 |
0 |
6 |
View |
| 6026155 |
chr10 |
1 |
1 |
0 |
2 |
View |
| 6031048 |
chr10 |
0 |
0 |
0 |
0 |
View |
Target gene [DOCK1] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
C GSE94732
|
Chip-seq |
24 |
Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens) |
|
GSE168557
|
Expression array |
6 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version) |
|
GSE52244
|
Expression array |
15 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version] |
|
GSE10789
|
Expression array |
6 |
NCI/ATC Hs-OperonV3 |
|
GSE189602
|
Methylation profiling (Array) |
4 |
Infinium MethylationEPIC |
|
GSE136189
|
Methylation profiling (Array) |
40 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE94732 - DOCK1 peak across samples
|
Peak Plot
|
|
|
HTLV1 Target gene Detail Information
