HTLV1 Target gene Detail Information

> DROSHA Gene Search Result


Gene Information
Gene Name DROSHA
Gene ID 29102
Gene Full Name drosha ribonuclease III
Gene Alias ETOHI2|HSA242976|RANSE3L|RN3|RNASE3L|RNASEN
Transcripts ENSG00000113360
Virus HTLV1
Gene Type protein-coding
HPA Location Info Nucleoplasm;Cytosol;
Membrane Info Cancer-related genes, Enzymes, Predicted intracellular proteins
Uniport_ID Q9NRR4
HGNC ID HGNC:17904
OMIM ID 608828
Summary This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq, Sep 2016]
Target gene [DROSHA] related to VISs

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section


DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6008322 chr5 37 5 4 46 View
6008630 chr5 10 10 23 43 View
6027707 chr5 2 0 0 2 View

Target gene [DROSHA] related to Omics data
Data ID Experiment type Sample number Platform
GSE189602 Methylation profiling (Array) 4 Infinium MethylationEPIC
C
  GSE94732 		Chip-seq 24 Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)
GSE52244 Expression array 15 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]
GSE10789 Expression array 6 NCI/ATC Hs-OperonV3
GSE224047 RNA-seq 10 Illumina NextSeq 500 (Homo sapiens)
GSE168557 Expression array 6 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version)


When the gene can detect a peak in the dataset, a peak plot will be displayed.


> Dataset: GSE94732 - DROSHA peak across samples

Peak Plot