HTLV1 Target gene Detail Information

> DUSP10 Gene Search Result


Gene Information
Gene Name DUSP10
Gene ID 11221
Gene Full Name dual specificity phosphatase 10
Gene Alias MKP-5|MKP5
Transcripts ENSG00000143507
Virus HTLV1
Gene Type protein-coding
HPA Location Info Nucleoplasm, Cytosol;
Membrane Info Enzymes, Predicted intracellular proteins
Uniport_ID Q9Y6W6
HGNC ID HGNC:3065
OMIM ID 608867
Summary Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Target gene [DUSP10] related to VISs

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section


DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6006446 chr1 28 17 23 68 View
6010949 chr1 28 0 0 28 View
6011946 chr1 18 4 2 24 View
6025710 chr1 1 1 1 3 View

Target gene [DUSP10] related to Omics data
Data ID Experiment type Sample number Platform
GSE189602 Methylation profiling (Array) 4 Infinium MethylationEPIC
C
  GSE94732 		Chip-seq 24 Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)
GSE52244 Expression array 15 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]
GSE10789 Expression array 6 NCI/ATC Hs-OperonV3
GSE224047 RNA-seq 10 Illumina NextSeq 500 (Homo sapiens)
GSE168557 Expression array 6 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version)
GSE136189 Methylation profiling (Array) 40 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip


When the gene can detect a peak in the dataset, a peak plot will be displayed.


> Dataset: GSE94732 - DUSP10 peak across samples

Peak Plot