Gene Name	ERN2
Gene ID	10595
Gene Full Name	endoplasmic reticulum to nucleus signaling 2
Gene Alias	IRE1-BETA|IRE1b|IRE2p|hIRE2p
Transcripts	ENSG00000134398
Virus	HTLV1
Gene Type	protein-coding
HPA Location Info	Endoplasmic reticulum, Cytosol;Intracellular and membrane;
Membrane Info	Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q76MJ5
HGNC ID	HGNC:16942
OMIM ID	604034
Summary	Enables several functions, including ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including apoptotic chromosome condensation; negative regulation of DNA-templated transcription; and rRNA catabolic process. Located in cytosol and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2025]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6008985	chr16	40	0	0	40	View
6032092	chr16	0	0	0	0	View

Data ID	Experiment type	Sample number	Platform
C   GSE94732	Chip-seq	24	Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)
GSE168557	Expression array	6	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version)
GSE52244	Expression array	15	[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]
GSE10789	Expression array	6	NCI/ATC Hs-OperonV3
GSE189602	Methylation profiling (Array)	4	Infinium MethylationEPIC
GSE136189	Methylation profiling (Array)	40	Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE94732 - ERN2 peak across samples

Peak Plot