Gene Information
|
Gene Name
|
FGA |
|
Gene ID
|
2243
|
|
Gene Full Name
|
fibrinogen alpha chain |
|
Gene Alias
|
AMYLD2|Fib2 |
|
Transcripts
|
ENSG00000171560
|
|
Virus
|
HBV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Endoplasmic reticulum;Secreted to blood; 
|
|
Membrane Info
|
Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted secreted proteins |
|
Uniport_ID
|
P02671
|
|
HGNC ID
|
HGNC:3661
|
|
OMIM ID
|
134820 |
|
Summary
|
This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. [provided by RefSeq, Jan 2016] |
Target gene [FGA] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 1010516 |
chr4 |
12 |
0 |
0 |
12 |
View |
| 1010517 |
chr4 |
12 |
0 |
0 |
12 |
View |
| 1012206 |
chr4 |
7 |
0 |
0 |
7 |
View |
| 1012207 |
chr4 |
7 |
0 |
0 |
7 |
View |
| 1013578 |
chr4 |
4 |
0 |
1 |
5 |
View |
| 1014581 |
chr4 |
1 |
0 |
2 |
3 |
View |
| 1014582 |
chr4 |
3 |
0 |
0 |
3 |
View |
| 1014583 |
chr4 |
3 |
0 |
0 |
3 |
View |
| 1019803 |
chr4 |
0 |
0 |
0 |
0 |
View |
| 1024505 |
chr4 |
0 |
0 |
0 |
0 |
View |
| 1040390 |
chr4 |
0 |
0 |
1 |
1 |
View |
| 1040391 |
chr4 |
0 |
0 |
1 |
1 |
View |
| 1040392 |
chr4 |
11 |
3 |
1 |
15 |
View |
| 1040393 |
chr4 |
21 |
11 |
0 |
32 |
View |
Target gene [FGA] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
S GSE252863
|
scRNA-seq |
10 |
Illumina HiSeq 2500 (Homo sapiens) |
|
GSE236281
|
RNA-seq |
12 |
Illumina MiSeq (Homo sapiens) |
|
C GSE35465
|
Chip-seq;RNA-seq |
6 |
Illumina HiSeq 2000 (Homo sapiens) |
|
C GSE68402
|
Chip-seq |
26 |
Illumina MiSeq (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens) |
|
TCGA_LIHC_HBV
|
DNA methylation sequencing;RNA-seq |
97 |
TCGA |
|
C GSE270130
|
Chip-seq |
27 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE224901
|
RNA-seq |
21 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE100400
|
Chip-seq;RNA-seq;4C_cccDNA |
31 |
Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Mus musculus) |
|
GSE173897
|
RNA-seq |
95 |
Illumina HiSeq 4000 (Homo sapiens) |
|
GSE262515
|
RNA-seq |
21 |
Illumina HiSeq 2500 (Homo sapiens);Illumina HiSeq 2500 (Mus musculus) |
|
GSE110345
|
RNA-seq |
4 |
Illumina HiSeq 2500 (Homo sapiens) |
|
C GSE131257
|
ATAC-seq;RNA-seq |
19 |
Illumina HiSeq 2500 (Homo sapiens) |
|
E GSE94660
|
RNA-seq |
42 |
Illumina HiSeq 2500 (Homo sapiens) |
When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.
> Dataset: GSE94660 - FGA expression across samples
|
Volcano Plot
|
Bar Plot
|
|
|
HBV Target gene Detail Information
