Gene Information
|
Gene Name
|
GRIN2A |
|
Gene ID
|
2903
|
|
Gene Full Name
|
glutamate ionotropic receptor NMDA type subunit 2A |
|
Gene Alias
|
EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A |
|
Transcripts
|
ENSG00000183454
|
|
Virus
|
HTLV1 |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Endoplasmic reticulum;Vesicles; 
|
|
Membrane Info
|
Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins, Transporters |
|
Uniport_ID
|
Q12879
|
|
HGNC ID
|
HGNC:4585
|
|
OMIM ID
|
138253 |
|
Summary
|
This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] |
Target gene [GRIN2A] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 6001389 |
chr16 |
403 |
46 |
6 |
455 |
View |
| 6006889 |
chr16 |
5 |
38 |
19 |
62 |
View |
| 6006963 |
chr16 |
5 |
37 |
19 |
61 |
View |
| 6018448 |
chr16 |
9 |
0 |
0 |
9 |
View |
| 6025931 |
chr16 |
2 |
0 |
0 |
2 |
View |
| 6027698 |
chr16 |
2 |
0 |
0 |
2 |
View |
| 6032995 |
chr16 |
0 |
0 |
0 |
0 |
View |
| 6033110 |
chr16 |
0 |
0 |
0 |
0 |
View |
Target gene [GRIN2A] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
C GSE94732
|
Chip-seq |
24 |
Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens) |
|
GSE168557
|
Expression array |
6 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version) |
|
GSE52244
|
Expression array |
15 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version] |
|
GSE189602
|
Methylation profiling (Array) |
4 |
Infinium MethylationEPIC |
|
GSE136189
|
Methylation profiling (Array) |
40 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE94732 - GRIN2A peak across samples
|
Peak Plot
|
|
|
HTLV1 Target gene Detail Information
