Gene Name	GRM5
Gene ID	2915
Gene Full Name	glutamate metabotropic receptor 5
Gene Alias	GPRC1E|MGLUR5|PPP1R86|mGlu5
Transcripts	ENSG00000168959
Virus	HTLV1
Gene Type	protein-coding
HPA Location Info	Intracellular and membrane;
Membrane Info	FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Uniport_ID	P41594
HGNC ID	HGNC:4597
OMIM ID	604102
Summary	This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6006672	chr11	0	62	3	65	View
6011368	chr11	10	6	11	27	View
6015834	chr11	1	12	0	13	View
6024536	chr11	1	2	0	3	View
6025466	chr11	1	2	0	3	View
6025467	chr11	1	2	0	3	View
6026410	chr11	0	2	0	2	View
6026872	chr11	2	0	0	2	View
6031802	chr11	0	0	0	0	View
6033242	chr11	0	0	0	0	View
6033415	chr11	0	0	0	0	View

Data ID	Experiment type	Sample number	Platform
C   GSE94732	Chip-seq	24	Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)
GSE168557	Expression array	6	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version)
GSE52244	Expression array	15	[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]
GSE10789	Expression array	6	NCI/ATC Hs-OperonV3
GSE189602	Methylation profiling (Array)	4	Infinium MethylationEPIC
GSE136189	Methylation profiling (Array)	40	Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE94732 - GRM5 peak across samples

Peak Plot