Gene Name	HLA-DRA
Gene ID	3122
Gene Full Name	major histocompatibility complex, class II, DR alpha
Gene Alias	HLA-DRA1
Transcripts	ENSG00000204287
Virus	HBV
Gene Type	protein-coding
HPA Location Info
Membrane Info	Plasma proteins, Predicted membrane proteins
Uniport_ID	P01903
HGNC ID	HGNC:4947
OMIM ID	142860
Summary	HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. This molecule is expressed on the surface of various antigen presenting cells such as B lymphocytes, dendritic cells, and monocytes/macrophages, and plays a central role in the immune system and response by presenting peptides derived from extracellular proteins, in particular, pathogen-derived peptides to T cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Aug 2020]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	38037048	A1762T	EnhII;BCP;PreC	C	Carcinoma, Hepatocellular Hepatitis B, Chronic Liver Cirrhosis	G C L T	View
2	38037048	A1846T	EnhII;BCP;PreC	C	Carcinoma, Hepatocellular Hepatitis B, Chronic Liver Cirrhosis	G C L T	View
3	38037048	C1653T	EnhII;BCP;PreC	C	Carcinoma, Hepatocellular Hepatitis B, Chronic Liver Cirrhosis	G C L T	View
4	38037048	G1719T	EnhII;BCP;PreC	C	Carcinoma, Hepatocellular Hepatitis B, Chronic Liver Cirrhosis	G C L T	View
5	38037048	G1764A	EnhII;BCP;PreC	C	Carcinoma, Hepatocellular Hepatitis B, Chronic Liver Cirrhosis	G C L T	View
6	38037048	G1896A	EnhII;BCP;PreC	C	Carcinoma, Hepatocellular Hepatitis B, Chronic Liver Cirrhosis	G C L T	View
7	38037048	G1899A	EnhII;BCP;PreC	C	Carcinoma, Hepatocellular Hepatitis B, Chronic Liver Cirrhosis	G C L T	View
8	38037048	T1674C	EnhII;BCP;PreC	C	Carcinoma, Hepatocellular Hepatitis B, Chronic Liver Cirrhosis	G C L T	View
9	38037048	T1674G	EnhII;BCP;PreC	C	Carcinoma, Hepatocellular Hepatitis B, Chronic Liver Cirrhosis	G C L T	View
10	38037048	T1753A	EnhII;BCP;PreC	C	Carcinoma, Hepatocellular Hepatitis B, Chronic Liver Cirrhosis	G C L T	View
11	38037048	T1753C	EnhII;BCP;PreC	C	Carcinoma, Hepatocellular Hepatitis B, Chronic Liver Cirrhosis	G C L T	View

Data ID	Experiment type	Sample number	Platform
S   GSE252863	scRNA-seq	10	Illumina HiSeq 2500 (Homo sapiens)
GSE236281	RNA-seq	12	Illumina MiSeq (Homo sapiens)
S   GSE199850	scRNA-seq	1	HiSeq X Ten (Homo sapiens)
C   GSE68402	Chip-seq	26	Illumina MiSeq (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens)
S   GSE247322	scRNA-seq	27	Illumina NovaSeq 6000 (Homo sapiens)
TCGA_LIHC_HBV	DNA methylation sequencing;RNA-seq	97	TCGA
GSE224901	RNA-seq	21	Illumina NovaSeq 6000 (Homo sapiens)
E   GSE100400	Chip-seq;RNA-seq;4C_cccDNA	31	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Mus musculus)
GSE173897	RNA-seq	95	Illumina HiSeq 4000 (Homo sapiens)
GSE262515	RNA-seq	21	Illumina HiSeq 2500 (Homo sapiens);Illumina HiSeq 2500 (Mus musculus)
GSE110345	RNA-seq	4	Illumina HiSeq 2500 (Homo sapiens)
GSE131257	ATAC-seq;RNA-seq	19	Illumina HiSeq 2500 (Homo sapiens)
GSE94660	RNA-seq	42	Illumina HiSeq 2500 (Homo sapiens)

• Expression profiling
• scRNA data
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: GSE100400 - HLA-DRA expression across samples

Volcano Plot

Bar Plot