Gene Name	IFNL3
Gene ID	282617
Gene Full Name	interferon lambda 3
Gene Alias	IFN-lambda-3|IFN-lambda-4|IL-28B|IL-28C|IL28B|IL28C
Transcripts	ENSG00000197110
Virus	HCV
Gene Type	protein-coding
HPA Location Info	Secreted to blood;
Membrane Info	Predicted secreted proteins
Uniport_ID	Q8IZI9
HGNC ID	HGNC:18365
OMIM ID	607402
Summary	This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	27812165	L159F	NS5B	NS5B	HCV Infection	D G R C L T	View
2	27812165	C316N	NS5B	NS5B	HCV Infection	D G R C L T	View
3	27812165	A421V	NS5B	NS5B	HCV Infection	D G R C L T	View
4	26368554	Y93H	NS5A	NS5A	HCV Infection	G C L T	View
5	27812165	L28M	NS5A	NS5A	HCV Infection	D G R C L T	View
6	27812165	R30Q	NS5A	NS5A	HCV Infection	D G R C L T	View
7	27812165	L31M	NS5A	NS5A	HCV Infection	D G R C L T	View
8	27812165	P58S	NS5A	NS5A	HCV Infection	D G R C L T	View
9	27812165	Y93H	NS5A	NS5A	HCV Infection	D G R C L T	View
10	27812165	T54S	NS3	NS3	HCV Infection	D G R C L T	View
11	27812165	R117H	NS3	NS3	HCV Infection	D G R C L T	View
12	27812165	S122T	NS3	NS3	HCV Infection	D G R C L T	View
13	27812165	S174F	NS3	NS3	HCV Infection	D G R C L T	View
14	25438153	R155K	Protease	NS3	Hepatitis C, Chronic	D G R C L T	View
15	25438153	V36M+R155K	Protease	NS3	Hepatitis C, Chronic	D G R C L T	View
16	25438153	V36M	Protease	NS3	Hepatitis C, Chronic	D G R C L T	View

Data ID	Experiment type	Sample number	Platform
TCGA_LIHC_HCV	DNA methylation sequencing;RNA-seq	97	TCGA
GSE126831	RNA-seq	63	Illumina NextSeq 500 (Homo sapiens)
GSE103730	Chip-seq;RNA-seq	42	Illumina HiSeq 2500 (Homo sapiens)
C   GSE103728	Chip-seq	24	Illumina HiSeq 2500 (Homo sapiens)
GSE211161	RNA-seq	4	Illumina HiSeq 2500 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE103728 - IFNL3 peak across samples

Peak Plot