HPV Target gene Detail Information

> LARGE1 Gene Search Result


Gene Information
Gene Name LARGE1
Gene ID 9215
Gene Full Name LARGE xylosyl- and glucuronyltransferase 1
Gene Alias LARGE|MDC1D|MDDGA6|MDDGB6
Transcripts ENSG00000133424
Virus HPV
Gene Type protein-coding
HPA Location Info
Membrane Info Disease related genes, Human disease related genes, Predicted intracellular proteins
Uniport_ID O95461
HGNC ID HGNC:6511
OMIM ID 603590
Summary This gene encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. The protein encoded by this gene is the glycotransferase that adds the final xylose and glucuronic acid to alpha-dystroglycan and thereby allows alpha-dystroglycan to bind ligands including laminin 211 and neurexin. Mutations in this gene cause several forms of congenital muscular dystrophy characterized by cognitive disability and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2018]
Target gene [LARGE1] related to VISs

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section


DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5005032 chr22 3 1 0 4 View
5007796 chr22 5 3 1 9 View
5009018 chr22 7 2 0 9 View
5009472 chr22 197 19 0 216 View
5011156 chr22 1 14 0 15 View
5016736 chr22 1 4 8 13 View

Target gene [LARGE1] related to Omics data
Data ID Experiment type Sample number Platform
C
  GSE183048 		Chip-seq 24 Illumina HiSeq 4000 (Homo sapiens)
GSE65858 Expression array 270 Illumina HumanHT-12 V4.0 expression beadchip
GSE181805 Expression array 25 [HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE138080 Expression array 35 Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
GSE140662 Expression array 8 [HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
C
  GSE143026 		ATAC-seq;Chip-seq;RNA-seq 30 Illumina HiSeq 2500 (Homo sapiens)
TCGA_CESC DNA methylation sequencing;RNA-seq 288 TCGA
GSE51993 Expression array 48 Illumina Human v2 MicroRNA expression beadchip;Illumina HumanHT-12 V4.0 expression beadchip


When the gene can detect a peak in the dataset, a peak plot will be displayed.


> Dataset: GSE183048 - LARGE1 peak across samples

Peak Plot

> Dataset: GSE143026 - LARGE1 peak across samples

Peak Plot