HTLV1 Target gene Detail Information

> LATS2 Gene Search Result


Gene Information
Gene Name LATS2
Gene ID 26524
Gene Full Name large tumor suppressor kinase 2
Gene Alias KPM
Transcripts ENSG00000150457
Virus HTLV1
Gene Type protein-coding
HPA Location Info Centriolar satellite, Cytosol;
Membrane Info Cancer-related genes, Enzymes, Predicted intracellular proteins
Uniport_ID Q9NRM7
HGNC ID HGNC:6515
OMIM ID 604861
Summary This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]
Target gene [LATS2] related to VISs

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section


DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6003092 chr13 138 36 9 183 View
6003094 chr13 137 37 9 183 View
6009100 chr13 30 9 0 39 View
6009530 chr13 30 6 0 36 View
6012433 chr13 7 9 6 22 View

Target gene [LATS2] related to Omics data
Data ID Experiment type Sample number Platform
GSE189602 Methylation profiling (Array) 4 Infinium MethylationEPIC
C
  GSE94732 		Chip-seq 24 Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)
GSE52244 Expression array 15 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]
GSE10789 Expression array 6 NCI/ATC Hs-OperonV3
GSE224047 RNA-seq 10 Illumina NextSeq 500 (Homo sapiens)
GSE168557 Expression array 6 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version)
GSE136189 Methylation profiling (Array) 40 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip


When the gene can detect a peak in the dataset, a peak plot will be displayed.


> Dataset: GSE94732 - LATS2 peak across samples

Peak Plot