Gene Information
|
Gene Name
|
LRRFIP2 |
|
Gene ID
|
9209
|
|
Gene Full Name
|
LRR binding FLII interacting protein 2 |
|
Gene Alias
|
HUFI-2 |
|
Transcripts
|
ENSG00000093167
|
|
Virus
|
HTLV1 |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Plasma membrane, Actin filaments; 
|
|
Membrane Info
|
Predicted intracellular proteins, Transcription factors |
|
Uniport_ID
|
Q9Y608
|
|
HGNC ID
|
HGNC:6703
|
|
OMIM ID
|
614043 |
|
Summary
|
The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017] |
Target gene [LRRFIP2] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 6000142 |
chr3 |
3061 |
478 |
349 |
3888 |
View |
| 6006302 |
chr3 |
64 |
7 |
0 |
71 |
View |
| 6022284 |
chr3 |
3 |
1 |
1 |
5 |
View |
Target gene [LRRFIP2] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE189602
|
Methylation profiling (Array) |
4 |
Infinium MethylationEPIC |
|
C GSE94732
|
Chip-seq |
24 |
Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens) |
|
GSE52244
|
Expression array |
15 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version] |
|
GSE10789
|
Expression array |
6 |
NCI/ATC Hs-OperonV3 |
|
GSE224047
|
RNA-seq |
10 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE168557
|
Expression array |
6 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version) |
|
GSE136189
|
Methylation profiling (Array) |
40 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE94732 - LRRFIP2 peak across samples
|
Peak Plot
|
|
|
HTLV1 Target gene Detail Information
