Gene Information
|
Gene Name
|
MARCHF1 |
|
Gene ID
|
55016
|
|
Gene Full Name
|
membrane associated ring-CH-type finger 1 |
|
Gene Alias
|
MARCH-I|MARCH1|RNF171 |
|
Transcripts
|
ENSG00000145416
|
|
Virus
|
HPV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Vesicles;Endoplasmic reticulum, Golgi apparatus; 
|
|
Membrane Info
|
Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
|
Uniport_ID
|
Q8TCQ1
|
|
HGNC ID
|
HGNC:26077
|
|
OMIM ID
|
613331 |
|
Summary
|
MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010] |
Target gene [MARCHF1] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 5015980 |
chr4 |
0 |
0 |
0 |
0 |
View |
| 5015981 |
chr4 |
0 |
0 |
0 |
0 |
View |
| 5015982 |
chr4 |
6 |
0 |
0 |
6 |
View |
Target gene [MARCHF1] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
C GSE183048
|
Chip-seq |
24 |
Illumina HiSeq 4000 (Homo sapiens) |
|
GSE181805
|
Expression array |
25 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
|
S GSE197461
|
scRNA-seq |
16 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE140662
|
Expression array |
8 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
|
TCGA_CESC
|
DNA methylation sequencing;RNA-seq |
288 |
TCGA |
|
C GSE143026
|
ATAC-seq;Chip-seq;RNA-seq |
30 |
Illumina HiSeq 2500 (Homo sapiens) |
When the query gene is differentially changed in the dataset, a feature/violin plot will be displayed.
> Dataset: GSE197461 - Gene expression in cell subsets
|
|
|
|
|
|
|
|
HPV Target gene Detail Information
