Gene Name	NKX1-1
Gene ID	54729
Gene Full Name	NK1 homeobox 1
Gene Alias	HSPX153|NKX-1.1|SAX2
Transcripts	ENSG00000235608
Virus	HPV
Gene Type	protein-coding
HPA Location Info	Cytosol;Nucleoli fibrillar center;
Membrane Info	Predicted intracellular proteins, Transcription factors
Uniport_ID	Q15270
HGNC ID	HGNC:24975
OMIM ID	617869
Summary	This gene encodes a transcription factor that belongs to NKX family of homeodomain-containing proteins which are critical regulators of organ development. In mice, the orthologous gene is expressed predominantly in the brainstem, in the vicinity of serotonergic neurons, and is required for the coordinated crosstalk of factors involved in the maintenance of energy homeostasis. Mice with a knockout of the orthologous gene lack subcutaneous fat and intra-abdominal epididymal and mesenteric white adipose tissue two weeks after birth, and die within three weeks after birth. [provided by RefSeq, Jul 2017]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5010829	chr4	25	0	0	25	View

Data ID	Experiment type	Sample number	Platform
M   GSE169622	Methylation profiling (Array)	9	Infinium MethylationEPIC
GSE196215	RNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
TCGA_CESC	DNA methylation sequencing;RNA-seq	288	TCGA
C   GSE143026	ATAC-seq;Chip-seq;RNA-seq	30	Illumina HiSeq 2500 (Homo sapiens)
GSE165883	RNA-seq	20	Illumina NextSeq 500 (Homo sapiens)

• Methylation profiling
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: GSE143026 - NKX1-1 peak across samples

Peak Plot