Virus Dataset Detail

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Dataset Information
Accession GSE196215
Status 2022/10/10
Title Human papillomavirus 42 is an oncogenic driver in Digital Papillary Adenocarcinoma [tumors]
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary The skin serves as a barrier to the environment and is constantly exposed to viral pathogens. However, whether and how viral pathogens contribute to oncogenesis of rare skin cancers has not been explored. We analyzed 18 skin cancers by exploiting sparse off-target reads from commonly available next-generation sequencing data and identify human papillomavirus 42 (HPV42) reads in digital papillary adenocarcinoma (DPA). We show that HPV42 recapitulates the molecular hallmarks of oncogenic HPVs and shares a conserved transcriptomic fingerprint of HPV-transformation. Finally, we show that HPV42 relies on established cellular targets of oncogenic HPVs for its transforming activity. The discovery of HPV42 as a novel oncogenic driver highlights the utility of next-generation sequencing data for the discovery of novel pathogen-disease associations and suggests expansion of current HPV vaccination programs to reduce the cancer burden in humans.
Samples
GSM ID Sample info Characteristics Description
GSM5862883 VR168 tissue:tumor; tissue type:digital papillary adenocarcinoma (DPA) -
GSM5862884 VR169 tissue:tumor; tissue type:digital papillary adenocarcinoma (DPA) -
GSM5862885 VR178 tissue:tumor; tissue type:digital papillary adenocarcinoma (DPA) -
GSM5862886 VR179 tissue:tumor; tissue type:digital papillary adenocarcinoma (DPA) -
GSM5862887 VR182 tissue:tumor; tissue type:digital papillary adenocarcinoma (DPA) -
GSM5862888 VR188 tissue:tumor; tissue type:digital papillary adenocarcinoma (DPA) -
GSM5862889 VR235 tissue:tumor; tissue type:digital papillary adenocarcinoma (DPA) -
GSM5862890 VR236 tissue:tumor; tissue type:digital papillary adenocarcinoma (DPA) -
Platform GPL24676  : Illumina NovaSeq 6000 (Homo sapiens)
Literature 36213965  
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xCell Plot
* p<0.05 ** p<0.01