Gene Information
|
Gene Name
|
NRG3 |
|
Gene ID
|
10718
|
|
Gene Full Name
|
neuregulin 3 |
|
Gene Alias
|
HRG3|pro-NRG3 |
|
Transcripts
|
ENSG00000185737
|
|
Virus
|
HTLV1 |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Vesicles;Secreted in brain; 
|
|
Membrane Info
|
Cancer-related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins |
|
Uniport_ID
|
P56975
|
|
HGNC ID
|
HGNC:7999
|
|
OMIM ID
|
605533 |
|
Summary
|
This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009] |
Target gene [NRG3] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 6007352 |
chr10 |
16 |
25 |
15 |
56 |
View |
| 6011168 |
chr10 |
10 |
7 |
10 |
27 |
View |
| 6014595 |
chr10 |
0 |
16 |
0 |
16 |
View |
| 6018367 |
chr10 |
7 |
1 |
1 |
9 |
View |
| 6018779 |
chr10 |
7 |
1 |
1 |
9 |
View |
| 6021045 |
chr10 |
6 |
0 |
0 |
6 |
View |
| 6024600 |
chr10 |
1 |
2 |
0 |
3 |
View |
| 6028693 |
chr10 |
0 |
0 |
1 |
1 |
View |
| 6028880 |
chr10 |
0 |
1 |
0 |
1 |
View |
Target gene [NRG3] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
C GSE94732
|
Chip-seq |
24 |
Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens) |
|
GSE168557
|
Expression array |
6 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version) |
|
GSE19080
|
Expression array |
38 |
Homo sapiens 3K Immunoarray2 HTLV-1 JH |
|
GSE189602
|
Methylation profiling (Array) |
4 |
Infinium MethylationEPIC |
|
GSE136189
|
Methylation profiling (Array) |
40 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE94732 - NRG3 peak across samples
|
Peak Plot
|
|
|
HTLV1 Target gene Detail Information
