Gene Information
|
Gene Name
|
NSMCE2 |
|
Gene ID
|
286053
|
|
Gene Full Name
|
NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase |
|
Gene Alias
|
C8orf36|MMS21|NSE2|ZMIZ7 |
|
Transcripts
|
ENSG00000156831
|
|
Virus
|
HTLV1 |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Nucleoplasm;Nuclear bodies; 
|
|
Membrane Info
|
Disease related genes, Human disease related genes, Predicted intracellular proteins |
|
Uniport_ID
|
Q96MF7
|
|
HGNC ID
|
HGNC:26513
|
|
OMIM ID
|
617246 |
|
Summary
|
This gene encodes a member of a family of E3 small ubiquitin-related modifier (SUMO) ligases that mediates the attachment of a SUMO protein to proteins involved in nuclear transport, transcription, chromosome segregation and DNA repair. The encoded protein is part of the structural maintenance of chromosomes (SMC) 5/6 complex which plays a key role genome maintenance, facilitating chromosome segregation and suppressing mitotic recombination. A knockout of the orthologous mouse gene is lethal prior to embryonic day 10.5. Naturally occurring mutations in this gene, that abolish the SUMO ligase activity, are associated with primordial dwarfism and extreme insulin resistance. [provided by RefSeq, Mar 2017] |
Target gene [NSMCE2] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 6001424 |
chr8 |
430 |
13 |
1 |
444 |
View |
| 6008903 |
chr8 |
32 |
2 |
7 |
41 |
View |
| 6013030 |
chr8 |
12 |
7 |
1 |
20 |
View |
| 6014892 |
chr8 |
14 |
1 |
0 |
15 |
View |
| 6019214 |
chr8 |
2 |
4 |
2 |
8 |
View |
Target gene [NSMCE2] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE189602
|
Methylation profiling (Array) |
4 |
Infinium MethylationEPIC |
|
C GSE94732
|
Chip-seq |
24 |
Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens) |
|
GSE52244
|
Expression array |
15 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version] |
|
GSE10789
|
Expression array |
6 |
NCI/ATC Hs-OperonV3 |
|
GSE224047
|
RNA-seq |
10 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE168557
|
Expression array |
6 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version) |
|
GSE136189
|
Methylation profiling (Array) |
40 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE94732 - NSMCE2 peak across samples
|
Peak Plot
|
|
|
HTLV1 Target gene Detail Information
