HTLV1 Target gene Detail Information

> OTOP1 Gene Search Result


Gene Information
Gene Name OTOP1
Gene ID 133060
Gene Full Name otopetrin 1
Gene Alias -
Transcripts ENSG00000163982
Virus HTLV1
Gene Type protein-coding
HPA Location Info
Membrane Info Predicted membrane proteins, Transporters
Uniport_ID Q7RTM1
HGNC ID HGNC:19656
OMIM ID 607806
Summary This gene encodes a transmembrane protein which belongs to the otopetrin domain protein family and is required for the formation of otoconia and otoliths, calcium carbonate biominerals within the inner ear of mammals that are required for the detection of linear acceleration and gravity. This gene modulates purinergic control of intracellular calcium in vestibular supporting cells. Naturally occurring mutations in the orthologous mouse gene are associated with nonsyndromic otoconia agenesis and a consequent balance defect. The orthologous mouse gene is also induced in white adipose tissue during obesity. The encoded protein is a component of a counterinflammatory pathway that attenuates obesity-induced adipose tissue inflammation and plays an adaptive role in maintaining metabolic homeostasis in obesity. [provided by RefSeq, Jul 2017]
Target gene [OTOP1] related to VISs

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section


DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6016464 chr4 10 2 0 12 View
6029528 chr4 1 0 0 1 View

Target gene [OTOP1] related to Omics data
Data ID Experiment type Sample number Platform
C
  GSE94732 		Chip-seq 24 Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)
GSE168557 Expression array 6 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version)
GSE52244 Expression array 15 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]
GSE10789 Expression array 6 NCI/ATC Hs-OperonV3
GSE189602 Methylation profiling (Array) 4 Infinium MethylationEPIC
GSE136189 Methylation profiling (Array) 40 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip


When the gene can detect a peak in the dataset, a peak plot will be displayed.


> Dataset: GSE94732 - OTOP1 peak across samples

Peak Plot