Gene Information
|
Gene Name
|
PAK5 |
|
Gene ID
|
57144
|
|
Gene Full Name
|
p21 (RAC1) activated kinase 5 |
|
Gene Alias
|
PAK7 |
|
Transcripts
|
ENSG00000101349
|
|
Virus
|
HPV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Nucleoplasm;Nuclear membrane, Mitochondria, Cytosol; 
|
|
Membrane Info
|
Enzymes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins |
|
Uniport_ID
|
Q9P286
|
|
HGNC ID
|
HGNC:15916
|
|
OMIM ID
|
608038 |
|
Summary
|
The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] |
Target gene [PAK5] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 5011756 |
chr20 |
0 |
0 |
0 |
0 |
View |
Target gene [PAK5] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
C GSE183048
|
Chip-seq |
24 |
Illumina HiSeq 4000 (Homo sapiens) |
|
GSE65858
|
Expression array |
270 |
Illumina HumanHT-12 V4.0 expression beadchip |
|
GSE181805
|
Expression array |
25 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
|
GSE140662
|
Expression array |
8 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
|
C GSE143026
|
ATAC-seq;Chip-seq;RNA-seq |
30 |
Illumina HiSeq 2500 (Homo sapiens) |
|
E TCGA_CESC
|
DNA methylation sequencing;RNA-seq |
288 |
TCGA |
|
GSE51993
|
Expression array |
48 |
Illumina Human v2 MicroRNA expression beadchip;Illumina HumanHT-12 V4.0 expression beadchip |
When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.
> Dataset: TCGA_CESC - PAK5 expression across samples
|
Volcano Plot
|
Bar Plot
|
|
|
HPV Target gene Detail Information
