Gene Information
|
Gene Name
|
PAM |
|
Gene ID
|
5066
|
|
Gene Full Name
|
peptidylglycine alpha-amidating monooxygenase |
|
Gene Alias
|
PAL|PAM-1|PHM |
|
Transcripts
|
ENSG00000145730
|
|
Virus
|
HTLV1 |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Golgi apparatus, Cytosol;Secreted in other tissues; 
|
|
Membrane Info
|
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins |
|
Uniport_ID
|
P19021
|
|
HGNC ID
|
HGNC:8596
|
|
OMIM ID
|
170270 |
|
Summary
|
This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] |
Target gene [PAM] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 6007203 |
chr5 |
33 |
25 |
0 |
58 |
View |
| 6012822 |
chr5 |
20 |
1 |
0 |
21 |
View |
| 6015916 |
chr5 |
8 |
5 |
0 |
13 |
View |
| 6023173 |
chr5 |
0 |
4 |
0 |
4 |
View |
| 6024332 |
chr5 |
2 |
1 |
0 |
3 |
View |
| 6030876 |
chr5 |
0 |
0 |
0 |
0 |
View |
Target gene [PAM] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE189602
|
Methylation profiling (Array) |
4 |
Infinium MethylationEPIC |
|
C GSE94732
|
Chip-seq |
24 |
Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens) |
|
GSE52244
|
Expression array |
15 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version] |
|
GSE10789
|
Expression array |
6 |
NCI/ATC Hs-OperonV3 |
|
GSE224047
|
RNA-seq |
10 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE168557
|
Expression array |
6 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version) |
|
GSE136189
|
Methylation profiling (Array) |
40 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE94732 - PAM peak across samples
|
Peak Plot
|
|
|
HTLV1 Target gene Detail Information
