Gene Information
|
Gene Name
|
PAPPA |
|
Gene ID
|
5069
|
|
Gene Full Name
|
pappalysin 1 |
|
Gene Alias
|
ASBABP2|DIPLA1|IGFBP-4ase|PAPA|PAPP-A|PAPPA1 |
|
Transcripts
|
ENSG00000182752
|
|
Virus
|
HTLV1 |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Secreted in female reproductive system; 
|
|
Membrane Info
|
Cancer-related genes, Candidate cardiovascular disease genes, Enzymes, Plasma proteins, Predicted secreted proteins |
|
Uniport_ID
|
Q13219
|
|
HGNC ID
|
HGNC:8602
|
|
OMIM ID
|
176385 |
|
Summary
|
This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017] |
Target gene [PAPPA] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 6021910 |
chr9 |
2 |
2 |
1 |
5 |
View |
| 6025303 |
chr9 |
3 |
0 |
0 |
3 |
View |
| 6025613 |
chr9 |
2 |
1 |
0 |
3 |
View |
Target gene [PAPPA] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
C GSE94732
|
Chip-seq |
24 |
Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens) |
|
GSE168557
|
Expression array |
6 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version) |
|
GSE52244
|
Expression array |
15 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version] |
|
GSE10789
|
Expression array |
6 |
NCI/ATC Hs-OperonV3 |
|
GSE189602
|
Methylation profiling (Array) |
4 |
Infinium MethylationEPIC |
|
GSE136189
|
Methylation profiling (Array) |
40 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE94732 - PAPPA peak across samples
|
Peak Plot
|
|
|
HTLV1 Target gene Detail Information
