Gene Information
|
Gene Name
|
PFKFB3 |
|
Gene ID
|
5209
|
|
Gene Full Name
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 |
|
Gene Alias
|
IPFK2|PFK2|iPFK-2 |
|
Transcripts
|
ENSG00000170525
|
|
Virus
|
HTLV1 |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Nucleoplasm; 
|
|
Membrane Info
|
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
|
Uniport_ID
|
Q16875
|
|
HGNC ID
|
HGNC:8874
|
|
OMIM ID
|
605319 |
|
Summary
|
The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016] |
Target gene [PFKFB3] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 6003463 |
chr10 |
13 |
57 |
89 |
159 |
View |
| 6007248 |
chr10 |
35 |
20 |
3 |
58 |
View |
| 6021509 |
chr10 |
5 |
1 |
0 |
6 |
View |
Target gene [PFKFB3] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE189602
|
Methylation profiling (Array) |
4 |
Infinium MethylationEPIC |
|
C GSE94732
|
Chip-seq |
24 |
Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens) |
|
GSE52244
|
Expression array |
15 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version] |
|
GSE10789
|
Expression array |
6 |
NCI/ATC Hs-OperonV3 |
|
GSE224047
|
RNA-seq |
10 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE168557
|
Expression array |
6 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version) |
|
GSE136189
|
Methylation profiling (Array) |
40 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE94732 - PFKFB3 peak across samples
|
Peak Plot
|
|
|
HTLV1 Target gene Detail Information
