HBV Target gene Detail Information

> PGPEP1 Gene Search Result


Gene Information
Gene Name PGPEP1
Gene ID 54858
Gene Full Name pyroglutamyl-peptidase I
Gene Alias PAP-I|PGI|PGP|PGP-I|PGPI|Pcp
Transcripts ENSG00000130517
Virus HBV
Gene Type protein-coding
HPA Location Info Golgi apparatus;
Membrane Info Enzymes, Predicted intracellular proteins
Uniport_ID Q9NXJ5
HGNC ID HGNC:13568
OMIM ID 610694
Summary The gene encodes a cysteine protease and member of the peptidase C15 family of proteins. The encoded protein cleaves amino terminal pyroglutamate residues from protein substrates including thyrotropin-releasing hormone and other neuropeptides. Expression of this gene may be downregulated in colorectal cancer, while activity of the encoded protein may be negatively correlated with cancer progression in colorectal cancer patients. Activity of the encoded protease may also be altered in other disease states including in liver cirrhosis, which is associated with reduced protease activity, and in necrozoospermia, which is associated with elevated protease activity. [provided by RefSeq, Jul 2016]
Target gene [PGPEP1] related to VISs

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section


DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1003079 chr19 58 30 80 168 View
1007652 chr19 0 2 23 25 View
1007653 chr19 0 2 23 25 View
1007654 chr19 0 2 23 25 View
1007655 chr19 0 2 23 25 View
1007674 chr19 0 2 23 25 View

Target gene [PGPEP1] related to Omics data
Data ID Experiment type Sample number Platform
GSE236281 RNA-seq 12 Illumina MiSeq (Homo sapiens)
C
  GSE35465 		Chip-seq;RNA-seq 6 Illumina HiSeq 2000 (Homo sapiens)
GSE199850 scRNA-seq 1 HiSeq X Ten (Homo sapiens)
C
  GSE68402 		Chip-seq 26 Illumina MiSeq (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens)
GSE247322 scRNA-seq 27 Illumina NovaSeq 6000 (Homo sapiens)
TCGA_LIHC_HBV DNA methylation sequencing;RNA-seq 97 TCGA
C
  GSE270130 		Chip-seq 27 Illumina NovaSeq 6000 (Homo sapiens)
GSE224901 RNA-seq 21 Illumina NovaSeq 6000 (Homo sapiens)
GSE100400 Chip-seq;RNA-seq;4C_cccDNA 31 Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Mus musculus)
GSE173897 RNA-seq 95 Illumina HiSeq 4000 (Homo sapiens)
GSE262515 RNA-seq 21 Illumina HiSeq 2500 (Homo sapiens);Illumina HiSeq 2500 (Mus musculus)
GSE110345 RNA-seq 4 Illumina HiSeq 2500 (Homo sapiens)
C
  GSE131257 		ATAC-seq;RNA-seq 19 Illumina HiSeq 2500 (Homo sapiens)
GSE94660 RNA-seq 42 Illumina HiSeq 2500 (Homo sapiens)


When the gene can detect a peak in the dataset, a peak plot will be displayed.


> Dataset: GSE35465 - PGPEP1 peak across samples

Peak Plot

> Dataset: GSE68402 - PGPEP1 peak across samples

Peak Plot

> Dataset: GSE270130 - PGPEP1 peak across samples

Peak Plot

> Dataset: GSE131257 - PGPEP1 peak across samples

Peak Plot