Gene Information
|
Gene Name
|
PLCB1 |
|
Gene ID
|
23236
|
|
Gene Full Name
|
phospholipase C beta 1 |
|
Gene Alias
|
DEE12|EIEE12|PI-PLC|PLC-154|PLC-I|PLC-beta-1|PLC154|PLCB1A|PLCB1B |
|
Transcripts
|
ENSG00000182621
|
|
Virus
|
HTLV1 |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Plasma membrane; 
|
|
Membrane Info
|
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
|
Uniport_ID
|
Q9NQ66
|
|
HGNC ID
|
HGNC:15917
|
|
OMIM ID
|
607120 |
|
Summary
|
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
Target gene [PLCB1] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 6009670 |
chr20 |
23 |
7 |
5 |
35 |
View |
| 6012348 |
chr20 |
20 |
0 |
3 |
23 |
View |
| 6013923 |
chr20 |
1 |
1 |
16 |
18 |
View |
| 6016343 |
chr20 |
5 |
6 |
1 |
12 |
View |
| 6019250 |
chr20 |
3 |
5 |
0 |
8 |
View |
| 6020766 |
chr20 |
6 |
0 |
0 |
6 |
View |
| 6022451 |
chr20 |
0 |
4 |
1 |
5 |
View |
| 6025105 |
chr20 |
3 |
0 |
0 |
3 |
View |
| 6029072 |
chr20 |
0 |
0 |
1 |
1 |
View |
| 6029852 |
chr20 |
1 |
0 |
0 |
1 |
View |
Target gene [PLCB1] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE189602
|
Methylation profiling (Array) |
4 |
Infinium MethylationEPIC |
|
C GSE94732
|
Chip-seq |
24 |
Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens) |
|
GSE52244
|
Expression array |
15 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version] |
|
GSE224047
|
RNA-seq |
10 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE168557
|
Expression array |
6 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version) |
|
GSE136189
|
Methylation profiling (Array) |
40 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE94732 - PLCB1 peak across samples
|
Peak Plot
|
|
|
HTLV1 Target gene Detail Information
