Gene Information
|
Gene Name
|
PPARGC1A |
|
Gene ID
|
10891
|
|
Gene Full Name
|
PPARG coactivator 1 alpha |
|
Gene Alias
|
LEM6|PGC-1(alpha)|PGC-1alpha|PGC-1v|PGC1|PGC1A|PPARGC1 |
|
Transcripts
|
ENSG00000109819
|
|
Virus
|
HTLV1 |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Nucleoplasm;Cytosol; 
|
|
Membrane Info
|
Cancer-related genes, Predicted intracellular proteins |
|
Uniport_ID
|
Q9UBK2
|
|
HGNC ID
|
HGNC:9237
|
|
OMIM ID
|
604517 |
|
Summary
|
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008] |
Target gene [PPARGC1A] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 6008400 |
chr4 |
20 |
5 |
20 |
45 |
View |
| 6012131 |
chr4 |
20 |
3 |
0 |
23 |
View |
| 6019712 |
chr4 |
7 |
0 |
0 |
7 |
View |
| 6019717 |
chr4 |
7 |
0 |
0 |
7 |
View |
| 6019722 |
chr4 |
7 |
0 |
0 |
7 |
View |
| 6019725 |
chr4 |
7 |
0 |
0 |
7 |
View |
| 6020057 |
chr4 |
6 |
1 |
0 |
7 |
View |
| 6023629 |
chr4 |
4 |
0 |
0 |
4 |
View |
| 6025547 |
chr4 |
2 |
0 |
1 |
3 |
View |
| 6029906 |
chr4 |
0 |
1 |
0 |
1 |
View |
| 6030238 |
chr4 |
1 |
0 |
0 |
1 |
View |
| 6030299 |
chr4 |
1 |
0 |
0 |
1 |
View |
Target gene [PPARGC1A] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
C GSE94732
|
Chip-seq |
24 |
Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens) |
|
GSE168557
|
Expression array |
6 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version) |
|
GSE52244
|
Expression array |
15 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version] |
|
GSE10789
|
Expression array |
6 |
NCI/ATC Hs-OperonV3 |
|
GSE189602
|
Methylation profiling (Array) |
4 |
Infinium MethylationEPIC |
|
GSE136189
|
Methylation profiling (Array) |
40 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE94732 - PPARGC1A peak across samples
|
Peak Plot
|
|
|
HTLV1 Target gene Detail Information
