Gene Information
|
Gene Name
|
PRKAA2 |
|
Gene ID
|
5563
|
|
Gene Full Name
|
protein kinase AMP-activated catalytic subunit alpha 2 |
|
Gene Alias
|
AMPK|AMPK2|AMPKa2|PRKAA |
|
Transcripts
|
ENSG00000162409
|
|
Virus
|
HTLV1 |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Nuclear speckles;Nucleoplasm, Golgi apparatus, Basal body, Cytosol; 
|
|
Membrane Info
|
Enzymes, FDA approved drug targets, Predicted membrane proteins, Transporters |
|
Uniport_ID
|
P54646
|
|
HGNC ID
|
HGNC:9377
|
|
OMIM ID
|
600497 |
|
Summary
|
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008] |
Target gene [PRKAA2] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 6022269 |
chr1 |
2 |
3 |
0 |
5 |
View |
| 6029665 |
chr1 |
1 |
0 |
0 |
1 |
View |
Target gene [PRKAA2] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
C GSE94732
|
Chip-seq |
24 |
Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens) |
|
GSE168557
|
Expression array |
6 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version) |
|
GSE52244
|
Expression array |
15 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version] |
|
GSE10789
|
Expression array |
6 |
NCI/ATC Hs-OperonV3 |
|
GSE189602
|
Methylation profiling (Array) |
4 |
Infinium MethylationEPIC |
|
M GSE136189
|
Methylation profiling (Array) |
40 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip |
When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.
> Dataset: GSE94732 - PRKAA2 peak across samples
|
Peak Plot
|
|
|
HTLV1 Target gene Detail Information
