Gene Information
|
Gene Name
|
PRKCE |
|
Gene ID
|
5581
|
|
Gene Full Name
|
protein kinase C epsilon |
|
Gene Alias
|
PKCE|nPKC-epsilon |
|
Transcripts
|
ENSG00000171132
|
|
Virus
|
HTLV1 |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Intermediate filaments, Cytosol;Vesicles, Plasma membrane; 
|
|
Membrane Info
|
Cancer-related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins |
|
Uniport_ID
|
Q02156
|
|
HGNC ID
|
HGNC:9401
|
|
OMIM ID
|
176975 |
|
Summary
|
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008] |
Target gene [PRKCE] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 6002361 |
chr2 |
154 |
56 |
40 |
250 |
View |
| 6005417 |
chr2 |
88 |
0 |
0 |
88 |
View |
| 6018081 |
chr2 |
7 |
2 |
0 |
9 |
View |
| 6018144 |
chr2 |
7 |
2 |
0 |
9 |
View |
| 6024890 |
chr2 |
3 |
0 |
0 |
3 |
View |
Target gene [PRKCE] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE189602
|
Methylation profiling (Array) |
4 |
Infinium MethylationEPIC |
|
C GSE94732
|
Chip-seq |
24 |
Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens) |
|
GSE52244
|
Expression array |
15 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version] |
|
GSE10789
|
Expression array |
6 |
NCI/ATC Hs-OperonV3 |
|
GSE224047
|
RNA-seq |
10 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE168557
|
Expression array |
6 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version) |
|
GSE136189
|
Methylation profiling (Array) |
40 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE94732 - PRKCE peak across samples
|
Peak Plot
|
|
|
HTLV1 Target gene Detail Information
