HTLV1 Target gene Detail Information

> RAPGEF2 Gene Search Result


Gene Information
Gene Name RAPGEF2
Gene ID 9693
Gene Full Name Rap guanine nucleotide exchange factor 2
Gene Alias CNrasGEF|NRAPGEP|PDZ-GEF1|PDZGEF1|RA-GEF|RA-GEF-1|RAGEF|Rap-GEP|nRap GEP
Transcripts ENSG00000109756
Virus HTLV1
Gene Type protein-coding
HPA Location Info Plasma membrane, Cytosol;
Membrane Info Disease related genes, Human disease related genes, Predicted intracellular proteins
Uniport_ID Q9Y4G8
HGNC ID HGNC:16854
OMIM ID 609530
Summary Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
Target gene [RAPGEF2] related to VISs

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section


DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6003119 chr4 156 9 16 181 View
6009367 chr4 29 6 2 37 View
6013680 chr4 5 13 0 18 View
6020127 chr4 6 1 0 7 View
6021465 chr4 5 1 0 6 View
6027695 chr4 0 1 1 2 View

Target gene [RAPGEF2] related to Omics data
Data ID Experiment type Sample number Platform
GSE189602 Methylation profiling (Array) 4 Infinium MethylationEPIC
C
  GSE94732 		Chip-seq 24 Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)
GSE52244 Expression array 15 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]
GSE10789 Expression array 6 NCI/ATC Hs-OperonV3
GSE224047 RNA-seq 10 Illumina NextSeq 500 (Homo sapiens)
GSE168557 Expression array 6 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version)
GSE136189 Methylation profiling (Array) 40 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip


When the gene can detect a peak in the dataset, a peak plot will be displayed.


> Dataset: GSE94732 - RAPGEF2 peak across samples

Peak Plot