HTLV1 Target gene Detail Information

> RAPGEF5 Gene Search Result


Gene Information
Gene Name RAPGEF5
Gene ID 9771
Gene Full Name Rap guanine nucleotide exchange factor 5
Gene Alias GFR|MR-GEF|MRGEF|REPAC
Transcripts ENSG00000136237
Virus HTLV1
Gene Type protein-coding
HPA Location Info Nucleoplasm;Nuclear bodies;
Membrane Info Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins
Uniport_ID Q92565
HGNC ID HGNC:16862
OMIM ID 609527
Summary Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
Target gene [RAPGEF5] related to VISs

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section


DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6004283 chr7 94 13 14 121 View
6008902 chr7 35 6 0 41 View
6014951 chr7 7 1 7 15 View
6018142 chr7 4 4 1 9 View
6018148 chr7 4 4 1 9 View

Target gene [RAPGEF5] related to Omics data
Data ID Experiment type Sample number Platform
GSE189602 Methylation profiling (Array) 4 Infinium MethylationEPIC
C
  GSE94732 		Chip-seq 24 Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)
GSE52244 Expression array 15 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]
GSE10789 Expression array 6 NCI/ATC Hs-OperonV3
GSE224047 RNA-seq 10 Illumina NextSeq 500 (Homo sapiens)
GSE168557 Expression array 6 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version)
GSE136189 Methylation profiling (Array) 40 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip


When the gene can detect a peak in the dataset, a peak plot will be displayed.


> Dataset: GSE94732 - RAPGEF5 peak across samples

Peak Plot