Gene Name	RAPGEF6
Gene ID	51735
Gene Full Name	Rap guanine nucleotide exchange factor 6
Gene Alias	KIA001LB|PDZ-GEF2|PDZGEF2|RA-GEF-2|RAGEF2
Transcripts	ENSG00000158987
Virus	HBV
Gene Type	protein-coding
HPA Location Info	Cytosol;Centrosome;
Membrane Info	Predicted intracellular proteins
Uniport_ID	Q8TEU7
HGNC ID	HGNC:20655
OMIM ID	610499
Summary	Enables several functions, including GTP-dependent protein binding activity; guanyl-nucleotide exchange factor activity; and phosphatidic acid binding activity. Involved in microvillus assembly; positive regulation of GTPase activity; and protein localization to plasma membrane. Located in several cellular components, including apical plasma membrane; centrosome; and endocytic vesicle. [provided by Alliance of Genome Resources, Apr 2025]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1005666	chr5	31	18	0	49	View
1005681	chr5	31	18	0	49	View
1020593	chr5	31	18	0	49	View
1043087	chr5	48	31	2	81	View

Data ID	Experiment type	Sample number	Platform
GSE236281	RNA-seq	12	Illumina MiSeq (Homo sapiens)
C   GSE35465	Chip-seq;RNA-seq	6	Illumina HiSeq 2000 (Homo sapiens)
C   GSE68402	Chip-seq	26	Illumina MiSeq (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens)
GSE247322	scRNA-seq	27	Illumina NovaSeq 6000 (Homo sapiens)
TCGA_LIHC_HBV	DNA methylation sequencing;RNA-seq	97	TCGA
C   GSE270130	Chip-seq	27	Illumina NovaSeq 6000 (Homo sapiens)
GSE224901	RNA-seq	21	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE100400	Chip-seq;RNA-seq;4C_cccDNA	31	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Mus musculus)
GSE173897	RNA-seq	95	Illumina HiSeq 4000 (Homo sapiens)
GSE262515	RNA-seq	21	Illumina HiSeq 2500 (Homo sapiens);Illumina HiSeq 2500 (Mus musculus)
GSE110345	RNA-seq	4	Illumina HiSeq 2500 (Homo sapiens)
C   GSE131257	ATAC-seq;RNA-seq	19	Illumina HiSeq 2500 (Homo sapiens)
GSE94660	RNA-seq	42	Illumina HiSeq 2500 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE35465 - RAPGEF6 peak across samples

Peak Plot

> Dataset: GSE68402 - RAPGEF6 peak across samples

Peak Plot

> Dataset: GSE270130 - RAPGEF6 peak across samples

Peak Plot

> Dataset: GSE100400 - RAPGEF6 peak across samples

Peak Plot

> Dataset: GSE131257 - RAPGEF6 peak across samples

Peak Plot