Gene Name	ROBO1
Gene ID	6091
Gene Full Name	roundabout guidance receptor 1
Gene Alias	CPHD8|DUTT1|NORS|NYS8|SAX3
Transcripts	ENSG00000169855
Virus	HTLV1
Gene Type	protein-coding
HPA Location Info	Plasma membrane;Primary cilium;
Membrane Info	Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q9Y6N7
HGNC ID	HGNC:10249
OMIM ID	602430
Summary	Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6004424	chr3	76	25	15	116	View
6010353	chr3	5	26	0	31	View
6012498	chr3	21	1	0	22	View
6016639	chr3	12	0	0	12	View
6017164	chr3	2	5	4	11	View
6018205	chr3	4	3	2	9	View
6021761	chr3	4	1	0	5	View
6026266	chr3	1	0	1	2	View
6026436	chr3	2	0	0	2	View
6026587	chr3	0	2	0	2	View
6028254	chr3	0	1	0	1	View
6028644	chr3	1	0	0	1	View
6028867	chr3	0	0	1	1	View
6029698	chr3	0	1	0	1	View
6029699	chr3	0	1	0	1	View
6029891	chr3	0	1	0	1	View
6030023	chr3	1	0	0	1	View
6031854	chr3	0	0	0	0	View
6033367	chr3	0	0	0	0	View

Data ID	Experiment type	Sample number	Platform
C   GSE94732	Chip-seq	24	Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)
GSE168557	Expression array	6	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version)
GSE52244	Expression array	15	[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]
GSE10789	Expression array	6	NCI/ATC Hs-OperonV3
GSE189602	Methylation profiling (Array)	4	Infinium MethylationEPIC
GSE136189	Methylation profiling (Array)	40	Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE94732 - ROBO1 peak across samples

Peak Plot