Gene Information
|
Gene Name
|
SERPINE1 |
|
Gene ID
|
5054
|
|
Gene Full Name
|
serpin family E member 1 |
|
Gene Alias
|
PAI|PAI-1|PAI1|PLANH1 |
|
Transcripts
|
ENSG00000106366
|
|
Virus
|
HBV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Secreted to blood; 
|
|
Membrane Info
|
Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted secreted proteins |
|
Uniport_ID
|
P05121
|
|
HGNC ID
|
HGNC:8583
|
|
OMIM ID
|
173360 |
|
Summary
|
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. The protein also functions as a component of innate antiviral immunity. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. [provided by RefSeq, Aug 2020] |
Target gene [SERPINE1] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
Target gene [SERPINE1] related to VISs
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 1024413 |
chr7 |
18 |
4 |
0 |
22 |
View |
| 1024417 |
chr7 |
18 |
4 |
0 |
22 |
View |
| 1024422 |
chr7 |
18 |
4 |
0 |
22 |
View |
Target gene [SERPINE1] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE236281
|
RNA-seq |
12 |
Illumina MiSeq (Homo sapiens) |
|
C GSE35465
|
Chip-seq;RNA-seq |
6 |
Illumina HiSeq 2000 (Homo sapiens) |
|
C GSE68402
|
Chip-seq |
26 |
Illumina MiSeq (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens) |
|
TCGA_LIHC_HBV
|
DNA methylation sequencing;RNA-seq |
97 |
TCGA |
|
C GSE270130
|
Chip-seq |
27 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE224901
|
RNA-seq |
21 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE100400
|
Chip-seq;RNA-seq;4C_cccDNA |
31 |
Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Mus musculus) |
|
GSE173897
|
RNA-seq |
95 |
Illumina HiSeq 4000 (Homo sapiens) |
|
GSE262515
|
RNA-seq |
21 |
Illumina HiSeq 2500 (Homo sapiens);Illumina HiSeq 2500 (Mus musculus) |
|
GSE110345
|
RNA-seq |
4 |
Illumina HiSeq 2500 (Homo sapiens) |
|
C GSE131257
|
ATAC-seq;RNA-seq |
19 |
Illumina HiSeq 2500 (Homo sapiens) |
|
GSE94660
|
RNA-seq |
42 |
Illumina HiSeq 2500 (Homo sapiens) |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE35465 - SERPINE1 peak across samples
|
Peak Plot
|
> Dataset: GSE68402 - SERPINE1 peak across samples
|
Peak Plot
|
> Dataset: GSE270130 - SERPINE1 peak across samples
|
Peak Plot
|
> Dataset: GSE131257 - SERPINE1 peak across samples
|
Peak Plot
|
|
|
HBV Target gene Detail Information
