Gene Name	STAT1
Gene ID	6772
Gene Full Name	signal transducer and activator of transcription 1
Gene Alias	CANDF7|IMD31A|IMD31B|IMD31C|ISGF-3|STAT91
Transcripts	ENSG00000115415
Virus	YFV
Gene Type	protein-coding
HPA Location Info	Nucleoplasm, Cytosol;
Membrane Info	Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Uniport_ID	P42224
HGNC ID	HGNC:11362
OMIM ID	600555
Summary	The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C. [provided by RefSeq, Jun 2020]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	26187414	E218A	NS5	NS5	Cell line	T	View

Data ID	Experiment type	Sample number	Platform
GSE243442	RNA-seq	55	Illumina NextSeq 500 (Homo sapiens)
E   GSE99081	RNA-seq	24	Illumina HiSeq 2500 (Homo sapiens)

• Expression profiling

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: GSE99081 - STAT1 expression across samples

Volcano Plot

Bar Plot