HTLV1 Target gene Detail Information

> UNC13B Gene Search Result


Gene Information
Gene Name UNC13B
Gene ID 10497
Gene Full Name unc-13 homolog B
Gene Alias MUNC13|UNC13|Unc13h2|munc13-2
Transcripts ENSG00000198722
Virus HTLV1
Gene Type protein-coding
HPA Location Info Vesicles;Nucleoplasm, Golgi apparatus, Intermediate filaments;
Membrane Info Predicted intracellular proteins
Uniport_ID O14795
HGNC ID HGNC:12566
OMIM ID 605836
Summary This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008]
Target gene [UNC13B] related to VISs

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section


DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6011128 chr9 12 5 10 27 View
6018645 chr9 0 9 0 9 View

Target gene [UNC13B] related to Omics data
Data ID Experiment type Sample number Platform
C
  GSE94732 		Chip-seq 24 Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)
GSE168557 Expression array 6 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version)
GSE52244 Expression array 15 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]
GSE10789 Expression array 6 NCI/ATC Hs-OperonV3
GSE189602 Methylation profiling (Array) 4 Infinium MethylationEPIC
GSE136189 Methylation profiling (Array) 40 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip


When the gene can detect a peak in the dataset, a peak plot will be displayed.


> Dataset: GSE94732 - UNC13B peak across samples

Peak Plot