Gene Name	VTN
Gene ID	7448
Gene Full Name	vitronectin
Gene Alias	V75|VN|VNT
Transcripts	ENSG00000109072
Virus	HBV
Gene Type	protein-coding
HPA Location Info	Endoplasmic reticulum, Vesicles;Secreted to blood;
Membrane Info	Cancer-related genes, Candidate cardiovascular disease genes, Plasma proteins, Predicted secreted proteins, Transporters
Uniport_ID	P04004
HGNC ID	HGNC:12724
OMIM ID	193190
Summary	The protein encoded by this gene functions in part as an adhesive glycoprotein. Differential expression of this protein can promote either cell adhesion or migration as it links cells to the extracellular matrix through a variety of ligands. These ligands include integrins, plasminogen activator inhibitor-1, and urokinase plasminogen activator receptor. This secreted protein can be present in the plasma as a monomer or dimer and forms a multimer in the extracellular matrix of several tissues. This protein also inhibits the membrane-damaging effect of the terminal cytolytic complement pathway and binds to several serpin serine protease inhibitors. This protein can also promote extracellular matrix degradation and thus plays a role in tumorigenesis. It is involved in a variety of other biological processes such as the regulation of the coagulation pathway, wound healing, and tissue remodeling. The heparin-binding domain of this protein give it anti-microbial properties. It is also a lipid binding protein that forms a principal component of high density lipoprotein. [provided by RefSeq, Aug 2020]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1002441	chr17	122	149	1	272	View
1002481	chr17	126	139	1	266	View
1039550	chr17	10	3	0	13	View
1039551	chr17	10	3	0	13	View
1039552	chr17	10	3	0	13	View
1039553	chr17	9	4	0	13	View
1039554	chr17	9	3	0	12	View
1039555	chr17	9	3	0	12	View
1039556	chr17	9	3	0	12	View
1039557	chr17	9	3	0	12	View
1039558	chr17	9	4	0	13	View
1039559	chr17	9	4	0	13	View
1039560	chr17	9	4	0	13	View
1039561	chr17	9	4	0	13	View

Data ID	Experiment type	Sample number	Platform
S   GSE252863	scRNA-seq	10	Illumina HiSeq 2500 (Homo sapiens)
GSE236281	RNA-seq	12	Illumina MiSeq (Homo sapiens)
C   GSE35465	Chip-seq;RNA-seq	6	Illumina HiSeq 2000 (Homo sapiens)
C   GSE68402	Chip-seq	26	Illumina MiSeq (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens)
TCGA_LIHC_HBV	DNA methylation sequencing;RNA-seq	97	TCGA
C   GSE270130	Chip-seq	27	Illumina NovaSeq 6000 (Homo sapiens)
GSE224901	RNA-seq	21	Illumina NovaSeq 6000 (Homo sapiens)
E   GSE100400	Chip-seq;RNA-seq;4C_cccDNA	31	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Mus musculus)
GSE173897	RNA-seq	95	Illumina HiSeq 4000 (Homo sapiens)
GSE262515	RNA-seq	21	Illumina HiSeq 2500 (Homo sapiens);Illumina HiSeq 2500 (Mus musculus)
GSE110345	RNA-seq	4	Illumina HiSeq 2500 (Homo sapiens)
C   GSE131257	ATAC-seq;RNA-seq	19	Illumina HiSeq 2500 (Homo sapiens)
GSE94660	RNA-seq	42	Illumina HiSeq 2500 (Homo sapiens)

• Expression profiling
• scRNA data
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: GSE100400 - VTN expression across samples

Volcano Plot

Bar Plot